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頁籤選單縮合
題名 | Positive Association between STAT3 and Ki-67 in Cervical Intraepithelial Neoplasia=子宮頸上皮內贅瘤中,STAT3的表現和Ki-67的表現呈現正相關 |
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作者 | 楊曉芳; 袁行修; 葉耀宗; 洪思齊; 吳明蒼; 蘇鈞煌; 蔡志仁; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷期 | 22:11 民95.11 |
頁次 | 頁539-546 |
分類號 | 417.2832 |
關鍵詞 | 子宮頸癌; 子宮頸上皮內贅瘤; Cervical cancer; Cervical intraepithelial neoplasia; STAT3; |
語文 | 英文(English) |
中文摘要 | STAT3 (signal transducer and activator of transcription 3) 在很多的癌症中被認為是一種致癌基因,然而它在子宮頸癌的致癌機轉中究竟扮演何種角色仍屬未知。本研究的目的即在評估 STAT3 在子宮頸上皮內贅瘤 (CIN)、正常子宮頸及子宮頸癌中的表現量以探討其在子宮頸癌致癌機轉中所可能扮演的角色。本實驗共蒐集了 83 個病例,包括 56 個 CIN 的病例,其中有 20 個 CIN 1、10 個 CIN 2 和 26 個 CIN 3 病例,以及 10 個正常子宮頸和 17 個 Ib 期的子宮頸鱗狀細胞癌的病例一起做比較。這些病例的石蠟切片經 STAT3 的免疫組織化學染色後再用半定量的方法判讀紀錄染色的結果,其結果和 CIN 組織病理的分級以及常用來表示細胞增生的標記 Ki-67,以 χ2 test 和 Fisher’s exact test 做統計分析比較。結果顯示:STAT3 主要表現在鱗狀上皮細胞的細胞核上,且組織病理分級高的 CIN 和鱗狀細胞癌的表現量比正常子宮頸上皮和 CIN 1 的表現量為高。同時,STAT3 在細胞核的表現量和 Ki-67 在細胞核的表現量呈現有意義的正相關 (p = 0.025),但其表現量和 CIN 的組織病理分級並無關聯性。我們的結果指出:STAT3 在 CIN 中的表現量多寡和細胞增生的程度有關,但其在子宮頸癌致癌機轉中可能沒有直接的貢獻。 |
英文摘要 | Signal transducer and activator of transcription 3 (STAT3) has been regarded as an oncogene in many types of cancers. However, its role in cervical carcinogenesis is not well determined. The purpose of this study was to evaluate the expression patterns of STAT3 in cervical intraepithelial neoplasia (CIN), normal cervix (NC), and squamous cell carcinoma (SCC) to explore its possible role in cervical carcinogenesis. Paraffin-embedded sections from 83 patients including 20 CIN 1, 10 CIN 2, 26 CIN 3, and 27 comparative cases of 10 NC and 17 stage Ib SCC were collected in this study. Immunohistochemistry was performed to analyze the expression patterns of STAT3, and the results obtained were categorized by a semiquantitative method and were further correlated with the CIN histopathologic grade and the proliferation marker, Ki-67, using the χ2 test. Our results showed that nuclear STAT3 expression was predominantly in the squamous epithelial cells, and that high-grade CIN and stage Ib SCC lesions had a higher nuclear STAT3 expression when compared with NC and CIN 1. Furthermore, the nuclear STAT3 expression in CIN was significantly correlated with Ki-67 expression (p = 0.025), but not CIN lesion grade. In summary, our results indicate that an altered STAT3 expression in CIN is correlated with cell proliferation but may not have a direct contribution to cervical carcinogenesis. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。