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題名 | 臍帶血幹細胞移植新發展=Advanced Development in Cord Blood Transplantation |
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作者 | 王玉祥; | 書刊名 | 秀傳醫學雜誌 |
卷期 | 6:3/4 民95.10 |
頁次 | 頁129-135 |
分類號 | 416.175 |
關鍵詞 | 造血幹細胞移植; 骨髓移植; 周邊血幹細胞移植; 臍帶血移植; Hematopoietic stem cell transplantation; Bone marrow transplantation; Peripheral blood stem cell transplantation; Cord blood transplantation; |
語文 | 中文(Chinese) |
中文摘要 | 造血幹細胞移植臨床應用已卅五載,已分別發展成為骨髓移植,周邊血幹細胞移植及臍帶血移植,治療適應症亦自血液疾病,先天性血色素病變及遺傳性免疫不全等疾病,擴展至抗癌治療與基因治療,此部份目前雖仍屬實驗階段,但已足以端倪出其美好遠景。骨髓移植最常見的三大障礙-接種失敗,移植物對抗宿主疾病及高復發率。亦由於周邊血幹細胞及臍帶血移植的演進,得以獲得部份解決。尢其臍帶血幹細胞移植有配對率高及發生急性移植物對抗宿主疾病率低等優點,已確定將成為造血幹細胞移植的主流。臍帶血移植是一待發掘的寶藏,它解決了幹細胞來源短缺的問題,但如何成功適用於成年患者是其未來發展的重點,讓我們拭目以待。 |
英文摘要 | Hematopoietic stem cell transplantation was developed clinically 35 years ago. Currently, bone marrow is not the only source for stem cell harvesting. Peripheral blood stem cell transplantation and cord blood transplantation were performed successfully in 1985 and 1988 respectively. In addition to the management of hematologic disease and hereditary metabolic disorder, hematopoietic stem cell transplantation arc crucially important in the field of anticancer treatment and gene therapy. Initially graft failure, graft versus host disease and recurrence of underlying illness were three major problems in bone marrow transplantation. The advantages of CBT are helpful for solving these troubles through specific immunologic mechanisms. Further effort into the studies of CBT should allow the development of effective transplantation for the highest number of adult patients. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。