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題名 | Metformin對血糖及骨骼肌肝醣儲存之影響=Oral Metformin Effects Blood Glucose and Stored Glycogen on Skeletal Muscle after Exercise |
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作者姓名(中文) | 林勁宏; 游文杉; 林志遠; 李文志; | 書刊名 | 輔仁大學體育學刊 |
卷期 | 5 民95.05 |
頁次 | 頁133-143 |
分類號 | 528.9012 |
關鍵詞 | 肝醣超載; 肌纖維; 葡萄糖吸收能力; Metformin; Glycogen supercompensation; Muscle fiber; Glucose uptake; |
語文 | 中文(Chinese) |
中文摘要 | Metformin與運動皆能增加骨骼肌對胰島素敏感性,因此本研究的主要目地為探討運動後再給予口服Metformin對肝醣儲存之影響,同時分析不同白肌與紅肌在肝醣儲存上的差異。30隻大白鼠(S.D.)以體重均分至三組,包括控制組(C)、運動組(E)及運動-Metformin組(EM),且給予運動-Metformin組每天每公斤500公克的Metformin為期5天,第五天給予2次3小時,中間間隔45分鐘之游泳運動測試後,立即以餵管方式給予所有動物,每公斤1克之50%(W/V)濃度葡萄糖溶液,分別於30分鐘後採取尾部血液進行血糖測量,分析葡萄糖吸收能力及5小時後取肌肉組織分析肝醣儲存量。研究結果顯示口服補充葡萄糖溶液30分鐘後運動-Metformin組血糖濃度明顯低於運動及控制組(C:106±4.52、E:92.7±3.95、EM:77.4±4.79 mg/dl, p<.05)。於5小時的葡萄糖回補後,發現運動及運動-Metformin組的股四頭紅肌,產生肝醣超載效應(C:31.9±2.18、E:49±10.2、EM:42.2±1.55mmol/kg),但Metformin的作用並沒有明顯增加肝醣儲存。相同的運動-Metformin的比目魚肌也無法產生正常的肝醣超載應效。研究顯示Metformin對於運動後肝醣超載之效果並無提昇作用。 |
英文摘要 | Exercise and metformin have both been found to enhance insulin sensitivity in vivo. Therefore, the purpose of the study was to determine the effect of post-exercise metformin administration on muscle glycogen storage in vivo condition. 30 Sprague-Dawley rats were evenly divided into 3 groups: control (C), exercise (E), and exercise-metformin (EM). Mettormin was only provided 500g daily for 5 days. Exercise protocol consists of 3 h X 2 swimming. Under fasted condition, rats were provided 1 g (50% V/W) glucose. Blood glucose was measured 30 min after oral glucose intubation. 5 h after exercise, muscle glycogen levels in red and white portion of the quadriceps muscle were measured. We found blood glucose concentration in EM group was significantly lower than the rest of groups C: 106±4.52、E: 92.7±3.95、EM: 77.4±4.79 mg/dl, p<.05). Glycogen supercompensation was only observed in the exercised muscle without metformin treatment Furthermore, metformin did not enhance muscle glycogen storage. In soleus, both exercise and metformin did not cause glycogen supercompensation. In conclusion, post-exercise metformin treatment did not enhance muscle glycogen storage. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。