查詢結果分析
相關文獻
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頁籤選單縮合
題 名 | Aberrant p53 Expression and the Development of Gallbladder Carcinoma and Adenoma=p53蛋白質在膽囊癌及膽囊腺瘤中之異常表現 |
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作 者 | 王森稔; 莊世昌; 蔡坤寶; 蔡志仁; 張文燦; 郭功楷; 陳榮祥; 李金德; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷 期 | 22:2 民95.02 |
頁 次 | 頁53-59 |
分類號 | 416.247 |
關鍵詞 | p53蛋白質; 免疫組織化學染色; 膽囊腺瘤; 膽囊癌; p53; Immunohistochemistry; Gallbladder adenoma; Gallbladder carcinoma; |
語 文 | 英文(English) |
中文摘要 | 膽囊癌是消化道中罕見卻又極具惡性的一種腫瘤,至於它是如何從膽囊腺瘤進展成膽囊癌,其機制目前並不清楚。在人類的惡性腫瘤中,p53 基因是最容易產生突變的一種腫瘤抑制基因。p53 蛋白質如果喪失功能,不僅使癌細胞不易發生凋亡,同時也和某些特定癌症的不良預後有密切關係。在本篇研究中,我們收集了 22 個膽囊癌、17 個膽囊腺瘤以及 15 個正常膽囊黏膜組織,利用免疫組織化學染色方法分析它們個別之 p53 蛋白質表現的情形,並將結果和其臨床及病理組織學的特性作一連結。結果發現,有 59.1% 的膽囊癌及 17.6% 的膽囊腺瘤表現 p53 蛋白質,而且兩者之表現情形呈現統計學上的差異(P 值等於 0.009)。在正常膽囊黏膜組織方面,則完全沒有呈現 p53 蛋白質免疫染色,同時其表現情形和膽囊癌的結果比較起來,呈現統計學上的差異(p 值小於 0.001)。另一方面,膽囊癌之 p53 蛋白質表現情形,和其組織學型態及癌細胞之分化情形並沒有呈現統計學上的關聯。本研究的結論支持,異常的 p53 蛋白質表現在膽囊癌的形成上扮演重要的角色。 |
英文摘要 | Gallbladder carcinoma (GBC) is a highly lethal but relatively rare neoplasm of the digestive tract. The progression from gallbladder adenoma to carcinoma remains unclear. The p53 gene is the most frequently mutated tumor suppressor in human cancers. In this study, we analyzed the expression patterns of the p53 protein in 22 cases of GBC, 17 cases of precursor lesions (16 gallbladder adenomas and 1 cystadenoma), and 15 cases of normal epithelia using immunohistochemical analysis. The results were correlated with clinicopathologic characteristics. We found that p53 expression was significantly increased in 59.1% (13/22) of GBC cases and in 17.6% (3/17) of gallbladder adenoma cases (p = 0.009). There was no p53 expression in the 15 cases of normal epithelia, and a significant difference was shown between normal epithelium and GBC cases (p < 0.001). In addition, the expression pattern of p53 protein did not show any significant correlation with the histologic type and the differentiation grade of GBC. In conclusion, we suggest that the aberrant p53 expression may play a role in the occurrence of GBC. |
本系統中英文摘要資訊取自各篇刊載內容。