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題 名 | Mutation of the p53 Tumor Suppressor Gene in Transitional Cell Carcinoma of the Urinary Tract in Taiwan=臺灣移形細胞癌p53腫瘤抑制基因的突變 |
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作 者 | 林鴻裕; 黃俊雄; 吳文正; 周以和; 范保羅; 龍佛衛; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷 期 | 21:2 民94.02 |
頁 次 | 頁57-64 |
分類號 | 415.138 |
關鍵詞 | p53基因的突變; 移形細胞癌; p53 gene; Transitional cell carcinoma; |
語 文 | 英文(English) |
中文摘要 | 此研究為了確認 p53 基因在泌尿道移形細胞癌中所扮演之角色。從 1992 年 3 月至 2003 年 7 月,有 75 位病人檢體加入此研究 (54 位男性病人,21 位女性病人)。其平均年齡是 66.85 歲。其中有 58 位膀胱癌的病人,8 位輸尿管癌的病人,以及9 位腎盂癌的病人。我們分別針對第 4,5,6,7 和 8 的位置之表現基因 (exon) 進行基因偵測。在病理學上,低分級 (low grade) 的腫瘤有37例,高分級 (high grade) 的腫瘤有 38 例。關於腫瘤分期 (stage),= pT1 分期有 29 位,= pT2 分期有 46 位。75 位病人中,47 位病人 (62.7%) 有 p53 基因的突變。47 個有基因突變的腫瘤,有 33 位病人 (70.2%) 是侵犯性的腫瘤 (invasive tumor)。統計分析指出,侵犯性的腫瘤則和 p53 基因突變在統計上有顯著的意義 (p < 0.05)。表現基因 4 (exon 4) 是 exons 4? 中最常見的突變基因,75位病人中有 20 位病人有基因突變的情形 (26.7%)。其中侵犯性的腫瘤有 15 位(75%),表淺性的腫瘤只有 5 位 (25%);高分級的腫瘤有 9 位 (45%),低分級的腫瘤有 11 位 (55%)。然而在 20 位 codon 72 異常的病人中,有 16 位是侵犯性的腫瘤佔 80%,4 位是表淺性的腫瘤佔 20%;14 位是高分級的腫瘤佔 70%,6 位是低分級的腫瘤佔 (30%)。侵犯性的腫瘤較容易產生 p53 基因的突變。利用聚合脢連鎖反應和單股序列型態多形性來做 p53 基因的簡單分析,對於偵測移形細胞癌 p53 基因的異常是適合的。在 p53 基因上的表現基因 exon 4 的 codon 72 多型性現象,與腫瘤之間的關係,需要進一步加以研究。 |
英文摘要 | Early detection of a mutated p53 gene is thought to provide useful information in a wide range of human tumors. The aim of this study was to identify the role of the p53 gene in transitional cell carcinoma of the urinary tract. From March 1992 to July 2003, 75 patients (54 men and 21 women) with a mean age of 66.85 years and pathologically diagnosed transitional cell carcinoma were enrolled in this study. Fifty-eight patients had bladder cancer, eight had ureteral cancer, and nine had renal-pelvic cancer. Rapid screening for mutation of the p53 gene was performed using polymerase chain reaction (PCR), single-strand conformation polymorphism (SSCP), and sequencing analysis. Primer sets were designed to amplify fragments within exons 4, 5, 6, 7, and 8 of the p53 gene. Pathology classified 37 tumors as low grade and 38 as high grade. Tumor stage was pT1 or less in 29 patients and at least pT2 in 46 patients. Of the 75 patients in this study, 47 (62.7%) had a p53 mutation. Of the patients with a p53 mutation, 33 (70.2%) had invasive tumors. Invasive tumors were associated with p53 mutation (p < 0.05). Noted in 20 patients (26.7%), exon 4 was the most common site of the mutation. Of the patients with exon 4 mutations, 15 (75%) had invasive tumors and nine (45%) had high-grade tumors. Additionally, among the 20 patients with a common polymorphism at codon 72, 16 (80%) had invasive tumors and 14 (70%) had high-grade tumors. In this study, 62.7% of patients with transitional cell carcinoma had a p53 mutation, suggesting that the p53 gene mutation may be used as a marker of transitional cell carcinoma. Invasive tumors are more likely to have a p53 gene mutation. A simple analysis of the p53 gene using PCR/SSCP is suitable for screening for p53 abnormalities in transitional cell carcinoma. The relationship between cancer risk and the codon 72 polymorphism of exon 4 needs further investigation. |
本系統中英文摘要資訊取自各篇刊載內容。