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題 名 | Current Therapeutic Advances in Chronic Interstitial Cystitis=慢性間質性膀胱炎最新治療方法 |
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作 者 | 郭漢崇; | 書刊名 | 慈濟醫學 |
卷 期 | 18:3 民95.06 |
頁 次 | 頁167-174+245 |
分類號 | 415.835 |
關鍵詞 | 間質性膀胱炎; 膀胱內治療; 藥物治療; Interstitial cystitis; Intravesical therapy; Medication; |
語 文 | 英文(English) |
英文摘要 | Interstitial cystitis (IC) is characterized by bladder pain associated with urgency, frequency, nocturia, dysuria and sterile urine. The diagnosis of this disease remains unclear and should be based on exclusion of other diseases. The possible etiologies of IC are (a) a post-infection autoimmune process, (2) mast cell activation induced by inflammation, toxins or stress, (3) urothelial dysfunction and increased permeability of the urotheliu, or (4) neurogenic inflammation. The priciples for treatment of IC asre based on (1) controlling the dysfunctional eptithelium by continual replenishment of the glycosaminoglycan (GAG) layer, (2) inhibiting neurological hyperactivity by administration of amitriptyline or imipramine, (3) suppression of allergies with antihistamines, and (4) pain control with non-steroid anti-inflammatory drugs (NSAID), Cox-2 inhibitors or tranquilizers. Intravesical treatment with heparin, hyaluroinc acid, chondroitin sulphate, bacillus Calmette-Guerin (BCG), dimethylsulphoxide (DMSO), resiniferatoxin, or botulinum A toxin has been shown effective in some patients. However, the placebo effect should be weighte3d and randomized, doubleblind trials should be undertaken to demonstrate the actual therapeutic effects of these therapeutic modalities. Since the etiology of IC is thought to be multi-factorial, multiple therapies might produce synergistic effects and a better outcome. For patients who are refractory to oral medication or intravesical instillation therapies, intravesical injections of botulinum A toxin or enuromodulation might provide symptomatic relief. |
本系統中英文摘要資訊取自各篇刊載內容。