頁籤選單縮合
題 名 | Isolation and Identification of a Vardenafil Analogue in a Functional Food Marketed for Penile Erectile Dysfunction=保健食品中摻加樂威壯類緣物成分之純化與鑑定 |
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作 者 | 賴國誌; 劉宜祝; 曾木全; 林雲蓮; 林哲輝; | 書刊名 | 藥物食品分析 |
卷 期 | 15:2 2007.06[民96.06] |
頁 次 | 頁133-138+208 |
分類號 | 412.36 |
關鍵詞 | 分離; 鑑定; Vardenafil analogue; Piperidenafil; Isolated; Identified; NMR; LC/MS/MS; |
語 文 | 英文(English) |
中文摘要 | 一種暗示具壯陽效果之食品,檢出非法摻加樂威壯類緣物(vardenafil analogue)成分,其結構經鑑定爲2-[2-ethoxy-5-(piperidine-1-sulfonyl)-phenyl]-5- methyl-7-propyl-3H-imidazo[5,1-f]-[1,2,4]triazin-4-one,並被命名爲 piperidenafil。該食品檢體先以乙醇萃取,經管柱層析分離純化處理後,再由一維與二維核磁共振儀(1H-NMR, 13C-NMR, COSY, DEPT, HMQC, HMBC)、紅外線吸收光譜儀(IR)、質譜分析儀(MS)及高效液相串聯式質譜儀(LC/MS/MS)等儀器鑑定其結構。爲保障民眾健康,已將此成分列為非法摻加西藥例行檢查項目之一。 |
英文摘要 | A vardenafil analogue was found to be added illegally to a dietary supplement marketed for erectile dysfunction. The structure was determined as 2-[2-ethoxy-5-(piperidine-1-sulfonyl)-phenyl]-5-methyl-7-propyl-3H-imidazo[5,1-f]-[1,2,4]triazin-4-one and named as piperidenafil. The sample was extracted with ethanol and isolated by column chromatography. The structure was identified by a series of 1-D and 2-D NMR techniques, mass and LC/MS/MS. As compared with the structure of vardenafil, it is shown that the ethylpiperazine was switched to piperidine. Since its structure was similar to that of vardenafil, side effects of vardenafil might be associated with this analogue. Basic on the law, foods using any illegal additive such as synthetic chemical compounds shall not be sold, manufactured, imported, processed, used, prepared, stored or transported. Therefore, this vardenafil analogue has been included in the inspection list of illegal health-related substances in Taiwan. |
本系統中英文摘要資訊取自各篇刊載內容。