頁籤選單縮合
題 名 | Peripheral Nerve Regeneration through Nerve Guides Filled with Bilobalide and Schwann Cells |
---|---|
作 者 | Lu, Ming-chin; Chang, Yung-hisen; Chiang, Leih-chih; Wang, Hai-ting; Cheng, Chun-yuan; Yao, Chun-hsu; Chen, Yueh-sheng; | 書刊名 | 醫學工程 |
卷 期 | 18:1 民95.02 |
頁 次 | 頁8-12 |
分類號 | 416.7 |
關鍵詞 | Schwann cells; Bilobalide; Silicone rubber nerve guide; Sciatic nerve; |
語 文 | 英文(English) |
英文摘要 | The present study provides in vivo trials of silicone rubber chambers filled with different concentrations of bilobalide (0, 50, 100, 200, 400μM) and Schwann cells (1.5 ×105 cell/ml) in a 1:1 volumetric addition to bridge a 15mm sciatic nerve defect in rats. At the conclusion of 8 weeks histological technique was used to evaluate the functional recovery of the nerve. In the groups receiving the Schwann cells and bilobalide at 50, 100, 200 and 400μM, 44% (4 of 9, one died during experiment), 50% (5 of 10), 30% (3 of 10), and 60% (6 of 10) of the animals exhibiting a regenerated nerve cable across the 15-mm gap, respectively. In comparison, 50% (5 of 10) of the animals in the group with Schwann cells only showed such regenerated nerve cables. Although the adding of bilobalide did not promote the nerve growth-promoting capability of Schwann cells in the nerve guides, the techniques we used in this study provided a new approach combining Chinese medicine and tissue engineering to nerve regeneration. |
本系統中英文摘要資訊取自各篇刊載內容。