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題名 | 利用核仁組成區嗜銀蛋白染色,以及增殖細胞核抗原、第四型膠原蛋白及板層素之免疫組織化學染色比較口腔疣狀上皮增生、疣狀癌與鱗狀細胞癌之差異=Comparison of the Differences among Oral Verrucous Hyperplasia, Verrucous Carcinoma, and Squamous Cell Carcinoma by Silver-Binding Nuclear Organizer Regions Stain and Immunohistochemical Staining of Proliferating Cell Nuclear Antigen, Type Ⅳ Collagen, and Laminin |
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作者 | 賴豐傑; 沈茂昌; 許漢銘; 蔡志仁; | 書刊名 | 中華皮膚科醫學雜誌 |
卷期 | 24:1 民95.03 |
頁次 | 頁1-8 |
分類號 | 415.138 |
關鍵詞 | 疣狀上皮增生; 疣狀癌; 鱗狀細胞癌; Verrucous hyperplasia; Verrucous carcinoma; Squamous cell carcinoma; Silver-binding muclear organizer regions stain; AgNORs; Proliferating cell nuclear antigen; PCNA; |
語文 | 中文(Chinese) |
中文摘要 | 口腔之疣狀上皮增生、疣狀癌及鱗狀細胞癌在臨床及組織學上的變化相當類似,特別是那些組織形態呈現邊緣型者。本研究目的希望藉由核仁組成區嗜銀蛋白染色,以及增殖細胞核抗原、第四型膠原蛋白及板層素之免疫組織化學染色,做為疣狀上皮增生、疣狀癌與鱗狀細胞癌之區別。共有31例的口腔疣狀上皮增生,32例的疣狀癌及66例的鱗狀細胞癌,均為石臘包埋的檔案材料。核仁組成區嗜銀蛋白染色數目在口腔上皮增生、疣狀癌及鱗狀細胞癌分別為每個細胞5.21±0.30,6.57±0.30及9.03±0.37。隨著惡性程度增加,核仁組成區嗜銀蛋白染色數目亦呈現有意義的增加。增殖細胞核抗原陽性細胞在疣狀癌呈連續性分佈於腫瘤巢外側2~3層細胞,而鱗狀細胞癌則呈現廣泛性散在分佈。增殖細胞核抗原之每一百個細胞之細胞陽性率在口腔上皮增生、疣狀癌及鱗狀細胞癌分別為7.85±1.52,13.83±1.69及29.46±2.03,亦呈現有意義的差別。第四型膠原蛋白及板層素免疫組織化學染色,在疣狀上皮增生及疣狀癌呈現完整基底膜染色,但在鱗狀細胞癌則呈現非連續的帶狀染色型態。由以上的結果,我們認為合併使用核仁組成區嗜銀蛋白染色及增殖細胞核抗原、第四型膠原蛋白及板層素之免疫組織化學染色,可做為口腔之疣狀上皮增生、疣狀癌與鱗狀細胞癌鑑別診斷上的參考。 |
英文摘要 | There were clinical and histological similarities among verrucous hyperplasia (VH), verrucous carcinoma (VC) and squamous cell carcinoma (SCC) of the oral cavity, especially, in those cases with borderline morphology. The aim of this study was to evaluate the differences among oral VH, VC and SCC by silver-binding nuclear organizer regions stain (AgNORs) and immunohistochemical staining for proliferating cell nuclear antigen (PCNA), type IV collagen and laminin. Thirty-one cases of VH, 32 cases of VC, and 66 cases of SCC were retrospectively retrieved from blocks of paraffin. The number of AgNORs in VH, VC and SCC were 5.21±0.30, 6.57±0.30 and 9.03±0.37per cell, respectively. As the degree of malignancy increased, the number of AgNORs significantly increased. Immunostaining showed that two to three layers of PCNA-positive cells were present in the peripheral area of the tumor nests of VC, but with a diffuse disseminated distribution in the tumor nests of SCCs. The positive rates of PCNA of every 100 cells on VH, VC and SCC were 7.85±1.52, 13.83±1.69 and 29.46±2.03, respectively, presenting significant differences. Immunostaining of type IV collagen and laminin in VH and VC displayed intact basement membrane, but presented non-continuous banding type in SCC. In light of the above results, we suggest that a combination of AgNORs and immunohistochemical staining of PCNA, type IV collagen, and laminin might be used as a method for distinguishing the differences among oral VH, VC and SCC. |
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