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題 名 | 控制釋放機制Higuchi模型中移動邊界層問題之探討=Moving Boundary Problem of Higuchi Model in Controlled Release Dose System |
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作 者 | 林松華; | 書刊名 | 宜蘭大學工程學刊 |
卷 期 | 1 2005.02[民94.02] |
頁 次 | 頁31-36 |
分類號 | 418.82 |
關鍵詞 | 可吸收高分子; 長效型服劑; 移動邊界層; Resorbable polymer; Long-term dosage; Moving boundary; |
語 文 | 中文(Chinese) |
中文摘要 | 近年來,由於人體可吸收之高分子材質以及長效型服劑系統在醫學上之重要性及其引進,使得藥物控制釋放之研究再度引起廣大的注意。在過去,雖然已有為數眾多之相關研究及其探討,其中包括實際之釋放系統和理論分析之模型,然而真正嚴謹、適當,而且完備之理論模型卻是極其有限,尤其是關於像是移動邊界層,有限週邊體積,有限界面阻力,以及有限藥劑溶解速度等等之較為複雜的控制釋放系統。在擬進行之研究中,吾人將著重理論分析於一般最為複雜而難以解決之移動邊界層問題之探討。鑑於過去在固定移動邊界層上常被引用之各種數值方法,其在物理意義上之合理性不足,故吾人採用Landau轉換及數值方法之運算,處理較簡單之Higuchi模型,並將所得結果與研究所得之確定模型及其分析結果,可提供做為臨床上長效型服劑之釋放系統設計時的重要依據及參考。 |
英文摘要 | The controlled release of the dose n a polymer matrix catches great attention again in recent years for the introduction of the resorbable polymer material and the long-term dosage systems. Although there are numerous applicable controlled release systems and theoretical discussion found in the literature, the rigorous and complete investigations are limited, especially for the more complex systems concerning the moving boundary problem, the finite circumstance volume, the finite interfacial resistance, and the finite dose's dissolution rate, etc. in the present stage, the study is aimed at the moving boundary problem, which is usually the knottiest encountered in controlled release. In view of the invalidity of fixing moving boundary methods adopted in previous study, we suggest a method combining Landau transform and numerical method. Through solving the simple Higuchi's model and comparison with the exact analytical solution, we examine the applicability of the present approach. In addition, the effects of systematic parameters, such as diffusivity, time, dose loading, etc., on the release rate of dose will also be inspected and confirmed. The theoretical model and the results derived from the study could be the important consultations for the design of the long-term dosage systems. |
本系統中英文摘要資訊取自各篇刊載內容。