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題 名 | 光敏感劑部花青素對鴨B型肝炎病毒之不活化試驗=A Study on Merocyanine 540 as a Photosensitizer for in Activating Duck Hepatitis B Virus |
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作 者 | 沈永紹; 高明見; 周世認; 林鎮洲; 賴建成; 許邦弘; | 書刊名 | 中華民國獸醫學會雜誌 |
卷 期 | 23:2 1997.04[民86.04] |
頁 次 | 頁103-113 |
分類號 | 437.73 |
關鍵詞 | 部花青素; 鴨B型肝炎病毒; 未照光; 預照光活化; MC540; DHBV; Non-light irradiated; Pre-light activated; |
語 文 | 中文(Chinese) |
中文摘要 | 本研究利用初代培養鴨B型肝炎病毒(duck hepatitis B virus, DHBV)陽性雛鴨 肝細胞系統作為活體系統, 探討光敏感劑部花青素 (MC540) 於不活化 DHBV 的可行性和效 果。 加入 MC540 與細胞一同培養,若未經照光 (non-light irradiated) 處理時,其對細 胞內 DHBV 的殺滅率約只有 50 %左右,且對 DHBV 之細胞外釋出率沒有影響。但若照光則 會抑制 DHBV 的增殖,其抑制效果與所加入劑量成正比,也和照光時間長短有關。當照光組 之 MC540 劑量為 140 μ g/mL 時,細胞內的 DHBV 幾乎全被殺滅,而培養液中病毒釋出率 僅約對照組之 1 %。 若 MC540 預照光活化 (pre-light activated) 後,再加入細胞於暗 室一同培養,既使不再照光,仍可有效抑制病毒的增殖。 當預照光之 MC540 劑量亦為 140 μ g/mL 時,即和照光之 MC540 有等強的抑制 DHBV 增殖效果。 |
英文摘要 | In the present study, the primary culture of duck hepatitis B virus (DHBV) positive ducklings' hepatocyte system was employed for investigating the feasibility and effectiveness of Merocyanine 540 (MC540), as a photosensitizer for inactivating DHBV. Adding the non-light irradiated MC540 to the cultured cells had about a 50% inactivation rate of intracellular DHBV but no influence on the extracellular release rate of DHBV. On the other hand, the primary ducklings' hepatocytes cultured with MC540 and irradiated by light showed inhibition of the replication of DHBV, with the inhibition rate dependent on the dosage and the irradiation time. With light irradiation, when the dosage of MC540 was 140 mg/mL, the inactivation of intracellular DHBV was almost complete, with the release rate in the medium lowered to about 1% of the control group's. Addition of pre-light activated MC540 was effective in inactivating DHBV without further light irradiation when cultured. The pre-light activated MC540 at a dosage of 140 μ g/m L could have the corresponding effectiveness of light irradiation. |
本系統中英文摘要資訊取自各篇刊載內容。