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題名 | 針刺止痛穴位在腦部磁場的變化=The Brain Magnetic Fields Elicited by Needling Analgesic Acupuncture Points |
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作者姓名(中文) | 龔彥穎; 陳方佩; 鄭州閔; 周志哲; 謝仁俊; | 書刊名 | 中華針灸醫學會雜誌 |
卷期 | 2004.12[民93.12] |
頁次 | 頁13-18 |
分類號 | 413.91 |
關鍵詞 | 針灸; 止痛; 磁腦波; Acupuncture; Analgesia; Magnetoencephalography; |
語文 | 中文(Chinese) |
中文摘要 | 針灸止痛的機轉目前認為跟活化中樞神經系統的疼痛調控路徑(pain modulatory pathway)及藉此分泌一些止痛介質(如內嗎啡)有關,但大腦皮質在針灸止痛上的角色不明。本研究即藉由磁腦波儀(magnetoencephalography,MEG)在大腦皮質有良好的空間和時間影像解析度之優點,來探討大腦皮質參與針刺止痛的相關區域之磁腦波訊號,希望藉此來了解針刺時人類腦部的磁場變化和大腦皮質在針灸止痛的角色。我們總共收集了12位健康的受試者(平均年齡22+2歲,男:女1:1),然後取每位受試者的合谷穴或魚際肌上的對照點,以頻率為1/3 HZ的電針予以刺激十分鐘。電針刺激時同時紀錄腦磁波的訊號,訊號收集完後再做1.5T的頭部磁振造影(MHI)影像。之後用Neuromag的軟體分析波形和大概活化的腦部偶極矩(dipole),然後將大概活化的腦部偶極矩與磁振造影影像結合,找出在大腦皮質確切活化的部位,予以統計分析。結果發現電針刺激合谷穴會產生對側的本體感覺區(SI)和兩側的次體感覺區次體感覺區(SII)活化,而對照點只有SI活化。就SI偶極矩來比較,合谷穴在SI的偶極矩大小明顯大於對照點的偶極矩(P<0.01)。結果表示電針刺激會使腦部產生磁場變化,穴位的大腦皮質偶極矩反應大於非穴位,且SII這個區域可能是大腦皮質參與針刺止痛的重要區域。 |
英文摘要 | Purpose: To investigate the role of human cerebral cortex in acupuncture analgesia by using magnetoencephalography (MEG) analysis. Materials and Methods: Twelve healthy subjects (mean age 22+2 years, male: female=1:1) were enrolled in this study. We randomized needled the acupuncture point L14 (Hegu) or control point at the thenar muscle with electrical stimulation with 1/3 Hz for 10 minutes. MEG recordings were obtained during the stimulation of electro-acupuncture simultaneously. Then the obtained data were analyzed by software of Neuromag. Activated dipoles were calculated and fitted to MRI imaging. The comparison between the magnitude of dipoles at different points were made by Student's t-test. Results: Electro-acupuncture at L14 resulted in activated dipoles at contralateral primary somatosensory area (SI) and bilateral secondary somatosensory area (SII) whereas electro-acupuncture at the control point only generated an activated dipole at SI. The magnitude of dipoles at SI during electro-acupuncture at L14 was significantly larger than that of the control point (p<0.01). Conclusion: The somatosensory elicited field by electro-acupuncture at L14 was significantly larger than that of the control point. SII is an important area for acupuncture analgesia. Evaluation of the effect of acupuncture analgesia by MEG recordings merits further investigation. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。