頁籤選單縮合
題名 | Clinical Experiences of Bacteremia Caused by Metallo-β-lactamase-producing Gram-negative Organisms=產生Metallo-β-Lactamase革蘭氏陰性菌菌血症之臨床經驗 |
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作者 | 李南瑤; 顏經洲; 李欣純; 劉恭宏; 黃紹宗; 柯文謙; | 書刊名 | 微免與感染雜誌 |
卷期 | 37:6 2004.12[民93.12] |
頁次 | 頁343-349 |
分類號 | 415.27 |
關鍵詞 | 革蘭氏陰性菌菌血症; Beta-lactamases; Bactermia; Carbapenems; Gram-negative bacteria; |
語文 | 英文(English) |
英文摘要 | The emergence of acquired metallo-β-lactamase (MBL) in Gram-negative bacilli is regarded as a therapeutic challenge since such enzymes are capable of hydrolyzing all β-lactams in vitro except the monobactams. The clinical characteristics and outcome of 8 episodes of Gram-negative bacteremia caused by MBL-producing isolates from January 1997 through December 2000 (Klebsiella pneumoniae, 6 isolates; Pseudomonas stutzeri, 4; Pseudomonas aeruginosa, 1; and Pseudomonas putida, 1) were analyzed. The median age of the patients was 61 years (range, 2-95 years). Most patients (n = 6, 75%) had more than 1 comorbid illness or condition and 6 patients acquired bacteremia in the intensive care unit. The median time from admission to the first positive culture was 34.5 days (range, 1-99 days). Pneumonia was the most common site of infection. Five patients (62.5%) received a carbapenem to treat bacteremia. The median time to defervescence was 6 days (range, 2-12 days). No bacteriologic failure was noted during or after antimicrobial therapy. The overall mortality rate from bacteremia caused by Gram-negative, MBL-producing organisms was nil at 14 or 28 days. |
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