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頁籤選單縮合
題名 | Genetic Influence on Serum Uric Acid Levels in Taiwanese=遺傳因素對血清尿酸濃度之影響--美兆健檢資料庫之分析 |
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作者 | 葉日弌; Yeh, Jih-i; |
期刊 | 慈濟醫學 |
出版日期 | 20041000 |
卷期 | 16:5 2004.10[民93.10] |
頁次 | 頁287-292 |
分類號 | 412.9 |
語文 | eng |
關鍵詞 | 尿酸; 分離分析; 回歸模型; Serum uric acid; Segregation analysis; Regressive model; |
中文摘要 | 目的:先前關於遺傳因素對血中尿酸濃度的影響的結論並不一致。為了瞭解在臺灣人口中尿酸濃度的遺傳是否有主要效果基因,本研究以臺灣美兆健檢資料庫的資料進行分離分析(segregation analysis)。材料與方法:在美兆健檢資料庫選出於1997至2001年間受檢的1,500個核心家庭,以線性回歸的方式,考慮受檢者的年齡、性別、體質指數、血清三酸甘油脂計算血清尿酸的殘差值,並將此殘差值以S.A.G. E.軟體中的FCOR程式計算親屬之間的相關係數,並估計血清尿酸濃度的可遺傳性,並用REGC指令進行分析,比較各種回歸遺傳模型(class D regressive models)的機率,以決定最可能的遺傳模式。結果:血清尿酸濃度的可遺傳性估計值為0.46。分析結果顯示,主要效果基因不會遺傳的模型被接受(χ²= 3.5, df=2, P=0.174)。其他所有包含主要效果基因的遺傳模型都被棄卻(主要效果基因為孟德爾式遺傳的模型:χ²= 67.3, df= 4, P=0.000,主要效果基因為非孟德爾式遺傳的模型:χ²= 54.6, df= 3, P=0.000)純環境影響模式也被棄卻(χ²= 21.2, df= 2 , P=0.0003)。結論:本研究顯示用一個符合孟德爾式遺傳的主要基因的模型無法解釋臺灣地區家庭內血清尿酸濃度的變化。血清尿酸濃度的中高程度的可遺傳性值得進一步研究。 |
英文摘要 | Objective: Previous studies on the inheritance of serum uric acid in Caucasian populations have not been consistent. To test if there is a major gene effect in the determination of serum uric acid levels in the Taiwanese population, several genetic models were tested by segregation analysis on data collected in Taiwan. Materials and Methods: The serum uric acid level and related health records of 5,384 individuals from 1,500 completely measured muclear families were selected from the MJ Health Screening Center Database. The serum uric acid levels were adjusted for age, age² and age³, body mass index and triglyceride by a linear regression model. The likelihoods of various class D regressive models of inheritance implemented in the Statistical Analysis for Genetic Epidemiology (S.A.G. E.) package were calculated for the adjusted serum uric acid level with the REGC program and compared. Results: The estimated heritability of serum uric acid level was 0.46. The model of no transmission of major gene effect was not rejected (χ²=3.5, df=2, P=0.174), and all models with a major gene effect were rejected by analysis using class D regressive models in S.A.G. E. (χ²=67.3, df=4, P=0.000 for Mendelian transmission of a major gene andχ²=54.6, df=3, P=0.000 for non-Mendelian transmission of a major gene). The environmental model hypothesis was also rejected (χ²=21.2, df=2, P=0.0003). Conclusions: The model of Mendelian transmission of serum uric acid level was vigorously rejected by segregation analysis. Our results do not support genetic models with an inherited major gene in the determination of serum uric acid levels in the Taiwanese population. |
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