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題 名 | Facial Telangiectasia-an Unusual Complication of Neonatal Lupus Erythematosus: Report of One Case=臉上毛細血管擴張-新生兒紅斑性狼瘡不常見的後遺症:一病例報告 |
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作 者 | 林聖傑; 徐世達; 吳俊誼; 黃立心; 馬益群; | 書刊名 | 臺灣兒科醫學會雜誌 |
卷 期 | 45:4 民93.07-08 |
頁 次 | 頁246-248+261 |
分類號 | 417.5945 |
關鍵詞 | 新生兒紅斑性狼瘡; 毛細血管擴張; 溶血性貧血; Neonatal lupus erythematosus; Telangiectasia; Hemolytic anemia; |
語 文 | 英文(English) |
中文摘要 | 新生兒紅斑性狼瘡主要是經由母體胎盤傳送的Anti-Ro/SSA、Anti-La/SSB或者是Anti-U1RNP抗體所造成的被動性自體免疫反應。其臨床上可以有皮膚紅斑、心臓房室阻斷、血液疾病或肝臓方面的問題。紅斑性狼瘡的皮疹通常是短暫的,在六個月之內隨著母體抗體消失而消褪。然而皮膚上持續性的毛細血管擴張,卻是紅斑性狼瘡不常見的一種後遺症。我們報告了一個三歲女孩,持續在臉上存在著毛細血管擴張。她在出生兩個月的時候,因爲皮膚上的紅斑、溶血性貧血、高濃度的ANA指數、陰性反應的Anti-Ro/SSA及Anti-La/SSA抗體,因而診斷爲新生兒紅斑性狼瘡。其母親亦爲紅斑性狼瘡的病人,有高濃度的ANA指數及陽性Anti-Ro/SSA/Anti-La/SSA抗體。這個女孩在出生六個月內,紅斑持續消褪,溶血性貧血也逐漸恢複,但是在三歲的時候,毛細血管擴張仍持續的存在。因此我們認爲新生兒紅斑性狼瘡的皮疹大部分會消失,但是不可忽略基們生毛細血管擴和的後遺症。 |
英文摘要 | Neonatal lupus erythematosus (NLE) is an uncommon passive autoimmune disease caused by transplacental passage of anti-Ro/SSA and/or anti-La/SSB or anti-UlRNP maternal autoantibodies. Common clinical manifestations include cutaneous lupus lesions, cardiac disease, notably congenital heart block, hematologic abnormalities, and hepatobiliary disease. The cutaneous lesions of NLE are usually transient, disappearing about six months after birth when maternal antibodies disappear from the infant's circulation. Persistent telangiectasia is a rare complication of NLE. We report a 3-year-old female who had cutaneous lupus with persistent facial telangiectasias over the frontal area. She was diagnosed with NLE at 2 months of age. Her findings then included cutaneous lupus, hemolytic anemia, a high titer of antinuclear antibodies (1: 640) with a speckled pattern, positive anti-Ro/SSA and anti-La/SSB antibodies, and absence of anti-dsDNA antibodies. Her mother had systemic lupus erythematosus with the presence of high titer of antinuclear antibodies (1: 1260) with a speckled pattern and positive anti-Ro/SSA and anti-La/SSB antibodies. The child’s cutaneous lupus and hemolytic anemia disappeared at 6 months of age. but the telangiectasia persisted. |
本系統中英文摘要資訊取自各篇刊載內容。