查詢結果分析
相關文獻
- Molecular Genetic Study of Hypertension
- 簡介定位基因位置的研究方法
- Cloning a Novel Metallophosphoesterase Gene from a Kidney cDNA Library of Hypertensive Rat
- AZFa Candidate Gene Deletions in Taiwanese Patients with Spermatogenic Failure
- Comparison of Superoxide Dismutase Gene Expression and Activity in the Hearts of Spontaneously Hypertensive and Normotensive Rats
- 長期血液透析尿毒症病患接受低劑量紅血球生成素治療的血壓及生化值變化
- Association between 894G>T Polymorphism in the Endothelial Nitric Oxide Synthase Gene and Circadian Variation of Blood Pressure in Patients with Essential Hypertension
- 豬隻腸毒素大腸桿菌、沙門氏桿菌及病毒性疾病抗病力候選基因之探討
- 豬遺傳標記與窩仔數候選基因之探討
- SREBP1c及ZBED6基因型與臺灣黃牛生長性狀相關性之探討
頁籤選單縮合
題名 | Molecular Genetic Study of Hypertension=高血壓的基因研究 |
---|---|
作者姓名(中文) | 陳澤浩; 江福田; | 書刊名 | Acta Cardiologica Sinica |
卷期 | 20:3 2004.09[民93.09] |
頁次 | 頁129-138 |
分類號 | 414.41 |
關鍵詞 | 高血壓; 基因; 相連性分析; 相關性分析; 候選基因; 基因標幟; Hypertension; Genetics; Linkage analysis; Association analysis; Candidate genes; Genetic markers; |
語文 | 英文(English) |
中文摘要 | 隨著社會的發展,高血壓的盛行率也跟著升高。數種家族性高血壓巳被確定由單基因突變所造成。這些研究也為高血壓與基因遺傳有關奠下了證據。本態性高血壓被認為是由多種基因的變異與環境的互動所造成。由於生理與血壓調控有關的基因稱為候選基因,大多數本態性高血壓的基因研究在於尋找本態性高血壓和候選基因的相關性。已有報告本態性高血壓與少數候選基因,例如血管張力素原基因,具有有意義的相關;然而其相關性仍因種族而有差別。也有利用多個標幟(markers)進行全基因體掃瞄,並發現數個與本態性高血壓相關的局部區域(locus);它們分佈於染色體2p,2q,5q,6q,15q,17,和18q等。一般預期高血壓動物之基因研究將有助於尋找本態性高血壓的致病基因,目前已有約二十個大鼠之高血壓相關的局部區域被定位。高血壓的基因研究將有助於高血壓的早期診斷、高血壓及心臟血管危險因子的分析、以及未來更個人化的治療。然而我們也要暸解高血壓基因研究的複雜性而且高血壓的基因變異可能因種族而有差異。 |
英文摘要 | Hypettension is a rising problem in the developed countries. Some rare familial hypertensive syndromes have been found to be caused by monogenic mutations. Essential hypertension is generally regarded as a complex genetic trait caused by multiple genes. The polygenic effects on blood pressure are modulated by gene-gene and gene-environment interactions. Most investigations for genetic causes of essential hypertension were approached with candidate genes, and a few candidate genes, such as angiotensinogen gene, were reported to be associated with essential hypertension, though the reports from different populations were still conflicting. Genome-wide scans with multiple markers have mapped several loci associated with blood pressure. The loci reported were on chromosomes 2p, 2q, 5q, 6q, 15q, 17, and 18q respectively. However, to date, no genotype had been conclusively linked to essential hypertension. It has long been hoped that genetic research on hypertensive animals, such as rats, will facilitate our understanding of the genetics of human essential hypertension. So far, more than twenty loci were reported to be associated with blood pressure in rate. More understanding of the genetic basis of essential hypertension should be possible in the future and would be expected to help earlier diagnosis, more effective risk factor assessment and more individualized treatment of hypertension. However, the difficulty of genetic analysis for essential hypertension and the possibility of inter-population differences in genetic factors should be kept in mind. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。