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題名 | 植入不同支架之血管受血液非牛頓流體性質影響下之脈衝式壁面剪應力變化=The Variations of Pulsatile Wall Shear Stress in Different Stented Vessel Affected by the Non-Newtonian Properties of Blood |
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作者 | 丁大為; 林俊義; | 書刊名 | Journal of Medical and Biological Engineering |
卷期 | 24:增刊 民93.04 |
頁次 | 頁S51-S59 |
分類號 | 398.34 |
關鍵詞 | 血管支架; 血液動力學; 非牛頓流體; 血球容積; 壁面剪應力; Vascular stent; Hemodynamics; Non-newtonian fluid; Hematocrit; Wall shear stress; |
語文 | 中文(Chinese) |
中文摘要 | 植入血管支架(vascular stents)已廣被醫師接受以施用於治療動脈狹窄。因血管支架植入後會造成血液擾動及剪應力變化,而血管支架附近之血液流動狀況與血栓(thrombosis)或再狹窄(restenosis)之發生有許多密切之關聯性,雖其機理尚未完全了解,但因血管支架之幾何結構設計而造成血液停滯或迴流區域出現等血液動力現象,應先進行研究。本研究乃利用計算流體力學模擬血管支架置入血管置入後,於血管支架附近所發生之血液動力現象。並利用冠狀動脈之脈衝式流量變化,以研究血液流經三種支架間距比(l/d=6、9、12)所造成之壁面剪應力變化。藉由比較牛頓流體與非牛頓流體之結果可顯示血液非牛頓流體性質對血管支架附近流場所造成之影響及其重要性。其中,於血管支架附近流場之速度及速度梯度受血液非牛頓流體性質影響而降低。另於部份時段,非牛頓流體性質所產生之栓流效應亦會影響血管支架頂端位置附近區域之流場,而造成支架頂端位置附近之壁面應變率值會大於牛頓流體所求得之結果,故限制血管支架表面所產生之最大剪應力值以避免紅血球被破壞,亦需作為血管支架結構設計之參考。 |
英文摘要 | The implantation of vascular stents has become more popular to treat occlusive vascular disease like stenosis. Some disturbed blood flow patterns or changes of wall shear stress distributions happened because of the implantation of the vascular stents. The close correlation between the flow phenomenon in the vicinity of the stent and the localization of restenosis or thrombosis of which the mechanism is not well known has led researchers to investigate the geometric design of vascular stents which is associated with the non-uniform features of hemodynamics such as recirculation, stagnation etc. By using the approaches of computational fluid dynamics the detailed information about the patterns of flow as the blood flows past the stent struts are obtained in this study. With use of the volume flow waveform of coronary artery the variation of pulsatile wall shear stress can be found for three different wire spacing design (l/d=6, 9, 12) of vascular stents. Comparing with reference of the Newtonian case the consequences of the presence of a stent on the flow of blood inherent with the non-Newtonian properties can provide insight into how the non-Newtonian properties affect the flow patterns within the stent and the importance of the non-Newtonian properties. Velocity and its gradient of the flow field nearby the stent are decreased by the introduction of the non-Newtonian properties. At some specific time, the plug flow induced by the non-Newtonian properties will affect the hemodynamic features in the region close to the stent and increase the wall shear rate on the top of the stent comparing the numerical result of Newtonian fluid. It should be considered that the maximum value of wall shear stress created on the surface of the stent has to be limited to avoid the breaking of red cell membrane to result in the improvement of the design of intravascular stents. |
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