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題名 | 每天兩公升1.1%胺基酸透析液對蛋白質熱量營養不良之慢性腹膜透析病人的體位測量和身體組成之影響=Effects of Daily Infusion of 2-L 1.1% Amino Acid Dialysateon Anthropometry and Body Composition of Chronic Peritoneal Dialysis Patients with Protein-Energy Malnutrition |
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作者 | 吳紅蓮; 曾進忠; 楊麗芬; 黃建鐘; 謝日耀; Wu, Hung-lien; Tseng, Chin-chung; Yang, Li-feng; Huang, Jeng-jong; Hsieh, Ryh-yaw; |
期刊 | 中華民國營養學會雜誌 |
出版日期 | 20040600 |
卷期 | 29:2 2004.06[民93.06] |
頁次 | 頁112-119 |
分類號 | 416.351 |
語文 | chi |
關鍵詞 | 蛋白質熱量營養不良; 腹膜透析; 白蛋白; 胺基酸透析液; 體位測量; 身體組成; 主觀整體營養評估; Protein-energy malnutrition; Peritoneal dialysis; Albumin; Amino acid dialysate; Subjective global assessment; Anthropometry; Body composition; |
中文摘要 | 接受腹膜透析(peritoneal dialysis, PD)治療的慢性尿毒癥病人,因蛋白質由透析液流失和蛋白質攝取不足,會導致蛋白質熱量營養不良(protein – energy malnutrition)的比例為44%,會增加病人的死亡率和罹病率。本研究是以每天一袋兩公升(2L)含1.1%胺基酸腹膜透析液給予腹膜透析患者,進行六個月之治療,以瞭解是否可以改善病人的體位測量和身體組成。收集國立成功大學附設醫院腹膜透析室15位的病人,且其血清白蛋白值(3.5 g/dL,每天交換一袋兩公升含1.1%胺基酸透析液(Nutrineal(上標 ®)),最後有12位患者(3位男或和9位女性)完成六個月的治療。結果發現血清白蛋白值以及主觀整體營養評估,沒有呈現有意義之變化;而體位測量方面,三頭肌皮層厚度有些許增加,中臂肌肉環圍與中臂肌肉面績有輕度減少,但無有意義之改變(p>0.05)。在身體組成方面,體脂肪量有上升的傾向(p=0.058),而瘦肌肉量有下降的趨勢(p=0.067);但是骨頭礦常粸含量方面沒有顯著之改變。總之,接受每天交換一袋兩公升的1.1%胺基酸透析液治療,並不會改變蛋白質熱量營養不良之慢性腹膜透析病人的體位測量和身體組成,可能需要更多的病人和更長的時間來觀察其變化。 |
英文摘要 | Protein-energy malnutrition, occurring in 44% of chronic uremic patients at the initiation of dialysis, is strongly associated with high morbidity and mortality rates. Many factors can engender the malnutrition, such as protein and amino acid losses in dialysate and inadequate protein intake. A total of 15 chronic peritoneal dialysis patients, with a serum albumin level of 3.5 g/dl and normalized protein equivalent of nitrogen appearance (nPNA) 0.9 gm/kg/day of ideal body weight, were enrolled into this study. And a daily infusion of 2-L 1.1 % amino acid dialysate (Nutrineal(superscript ®)) was administered over six months. There were 12 patients (3 male and 9 female) completed this study. Assessments of serum albumin, anthropometry, and body compositions by dual energy X-ray absorptiometry (DEXA) were performed before and after six months of Nutrineal(superscript ®) treatment. No significant change was found in serum albumin level and subjective global assessment. There were a small, but insignificant, increment of triceps skin fold, and a decrease, but of no significance, in mid-arm muscle circumference or muscle area. Also, there were a trend to decline in lean body mass and a tendency increase in body fat mass before and after six months of Nutrineal(superscript ®) treatment. In addition, bone mineral content did not change during this period. These findings indicated that daily administration of 2-L 1.1% amino acid dialysate for six months in malnourished patients on chronic peritoneal dialysis did not improve the anthropometry and change the body composition. |
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