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題名 | Cord Blood Myeloperoxidase in Preterm Infants with Periventricular Hyperechogenicity=臍帶血Myeloperoxidase造成早產兒之腦室周圍高超音波值 |
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作者姓名(中文) | 王建安; 楊崑德; 黃崇濱; 黃新純; 黃立同; | 書刊名 | 長庚醫學 |
卷期 | 27:5 2004.05[民93.05] |
頁次 | 頁337-343 |
分類號 | 417.5171 |
關鍵詞 | 早產兒; 腦室周圍高超音波值; 細胞素; 沾粘分子; 發炎介質; Premature; Cytokine; Adhesion molecule; Inflammatory mediator; Myeloperoxidase; Periventricular hyperechogenicity; |
語文 | 英文(English) |
中文摘要 | 背景:在腦白質病變的病理生理機轉中,細胞素(cytokines)、沾粘分子(adhesion molecules)和發炎介質(inflammatory mediators)認為扮演中心的角色。為了研究早產兒臍帶血中細胞素、沾粘分子和發炎介質和腦部超音波中腦室周圍高超音波值(periventricular hyperechogenicity-PVH)之間的關係,從96位早產兒裡檢查臍炎血中細胞素、沾粘分子、發炎介質和腦部超音波。 方法:非PVH組為20位早產兒第一周大時為正常之腦部超部波,PVH組為20早產兒第一周大時為腦室周圍高音波值之腦部超音波。早產兒生後用酵素螢光免疫分析法檢查臍帶血之細胞素、沾粘分子和發炎介質包括IL-8、PGE2、P-selectin、sVCAM和MPO。 結果:IL-8、PGE2、P-selectin和sVCAM的值在兩組中並沒有顯著差異。有趣的是唯一有顯著差異為有腦室周圍高超音波值中之MPO值比沒有腦室周圍高超音波值高(7.36±3.6vs.4.81±3.5; p=0.024)。 結論:我們認為中性顆粒球中之MPO在早產兒腦室周圍高超波值之出或許有相關性。 |
英文摘要 | Backgorund: Cytokines, adhesion molecules, and inflammatory mediators are believed to play central roles in the pathophysiologic mechanisms of brain white matter lesions. To examine the relationships of cytokines, adhesion molecules, and inflammatory mediators in the cord blood of preterm infants and neonatal cerebral ultrasound periventricular hyperechogenicity (PVH), cord blood cytokines, adhesion molecules, and inflammatory mediators were analyzed, and routine cerebral ultrasound scans were performed in all 96 premature infants. Methods: The non-PVH group consisted of 20 infants with normal cerebral ultrasound findings during the first week of life. The PVH group consisted of 20 infants with PVH during the first week of life. Cytokines, adhesion molecules, and inflammatory mediators in cord blood including interleuking-8 (IL-8), prostaglandin E2 (PGE), P-selectin, sluble vascular cell adhesion molecules (sVCAMs), and myeloperoxidase (MPO) were examined by enzyme-linked immunosorbent assay. Results: There were no significant differences in IL-8, PGE2, P-selecin, and sVCAM levels between patients with and without PVH. Interestingly, MPO levels were marginally significantly higher in patients with PVH than those without PVH (7.46±3.6 vs. 4.81±3.5; p=0.024). Conclusions: It is concluded that MPO from leukocytes may contribute to the occurrence of PVH in premature infants. |
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