查詢結果分析
相關文獻
頁籤選單縮合
題 名 | Altered Sialylation and Sialyltransferase Expression in Gynecologic Cancers |
---|---|
作 者 | Wang,Peng-hui; | 書刊名 | Taiwanese Journal of Obstetrics & Gynecology |
卷 期 | 43:2 2004.06[民93.06] |
頁 次 | 頁53-63 |
分類號 | 417.3 |
關鍵詞 | Neoplasms of the cervix; Prognosis; Sialic acid; Sialyltransferase; |
語 文 | 英文(English) |
英文摘要 | Sialic acids and their derivatives are ubiquitous at the terminal positions of the oligosaccharides of glycoproteins that play roles in a variety of biologic processes, such as cell-cell communication, cell-matrix interaction, adhesion, and protein targeting. Altered sialyltransferase (ST) expression plays an important role in oncogenesis, tumor progression, and lymph node metastases. For example, in squamous cell carcinoma of the cervix, α2,6-ST I shows positive correlation not only with oncogenesis, but also with tumor metastases to the pelvic lymph node metastases in squamous cell carcinoma of the cervix. This laboratory successfully cIoned α2,3-,a2,6-, and α2,8-ST genes to screen a powerful anti-ST reagent, soyasaponin I (Ssal). Ssal is not cytocidal but, in contrast, has a cytostatic effect on cancer cells, mainly slowing cell growth and division. It also modifies the invasive behavior of cancer cells such as migration and adhesion. Thus, altered glycosylation is important in gynecologic cancers, especially squamous cell carcinoma of the cervix. In future, the functional roles of ST in cancer pathogenesis may be elucidated. For example, specific anti-ST inhibitors could clarify the role of changing sialylation in cancer behavior, monoclonal antibodies to certain glycosylated epitopes will help diagnosis of such tumors and, most importantly, both these techniques will offer therapeutic avenues designed to attack tumor cells via their glycans in the near future. |
本系統中英文摘要資訊取自各篇刊載內容。