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題 名 | Anodic Polarographic Determination of Lansoprazole and Omeprazole in Pure form and in Pharmaceutical Dosage Forms=利用陽極極譜分析法檢測純態及劑型之Lansoprazole與Omeprazole |
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作 者 | Belal,Fathalla; El-Enany,Nahed; Rizk,Mohamed; | 書刊名 | 藥物食品分析 |
卷 期 | 12:2 2004.06[民93.06] |
頁 次 | 頁102-109+194 |
分類號 | 341.95 |
關鍵詞 | 極譜分析法; 陽極電流模式; 劑型; Lansoprazole; Omeprazole; Dosage forms; Polarography; Anodic current mode; |
語 文 | 英文(English) |
中文摘要 | Lansoprazole (LNS) 與Omeprazole (OMP) 兩者為醫療上舉足輕重的藥劑,確實需要一種簡單、可靠的方法來分析與確保其在錠劑中的成分均一性。在pH4.1-11.55之Britton-Robinson緩衝溶液 (BRb) 中,LNS及OMP的陽極極譜表現已被研究。在pH7之BRb中,LNS克OMP的擴散電流常數 (10) 分別為1.70±0.01 (n=6) 及1.66±0.01 (n=8) 時,產生了明確的陽極波。在LNS及OMP的濃度範團分別為4-24及2-16μgmL-1的條件下,利用直流電 (DCt) 模式;以及在LNS及OMP的濃度範團分別為2-18及0.4-12μgmL-1的條件下,利用鑑別脈動式極譜分析 (DPP) 模式,所得到的電流濃度關係圖示均呈線性。DPP模式對LNS及OMP的檢測極限 (S/N=2) 分別為0.2μgmL-1 (5.41×10-7M) 及0.05μgmL-1 (1.45×10-7M) 。這項被提出的方法,已經成功地應用在商業化藥片中LNS及OMP的分析。在令人滿意的標準偏差下,本分析方法較參考方法有更佳的平均百分比回收率。兩種情況的電極反應路徑被假設,結果顯示所提出的方法是簡單,準確與再現性佳之分析方法。 |
英文摘要 | Lansoprazole (LNS) and omeprazole (OMP) are therapeutically important drugs, and the need arose for a simple, reliable method for their content uniformity of their tablets. The anodic polarographic behavior of lansoprazole and omeprazole has been studied in Britton-Robinson buffer (BRb) over the pH range 4.1-11.5. In BRb of pH 7 well-defined anodic waves were produced with diffusion-current constant (Id) of 1.70 ± 0.01 (n = 6) and 1.66 ± 0.01 (n = 8) for LNS and OMP, respectively. The current-concentration plots were rectilinear over the ranges of 4-24, 2-16 μg mL-1 using Direct Current (DCt) mode for LNS and OMP, respectively and over the range 2-18, 0.4-12 μg mL-1 using the Differential Pulse Polarographic (DPP) mode for LNS and OMP, respectively. The detection limits (S/N = 2) using DPP mode were 0.2 μg mL-1 (5.41 × 10-7 M) and of 0.05 μg mL-1 (1.45 × 10-7 M) for LNS and OMP, respectively. The proposed method was successfully applied to the analysis of the two drugs in their commercial capsules. The average percent recoveries were favorably compared to those obtained by reference methods, with satisfactory standard deviations. A pathway for the electrode reaction in both cases was postulated. The proposed method is characterized by being simple, accurate and stability-indicating. |
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