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題名 | Comparative Efficacy of Nebulized Budesonide to Intravenous Betamethasone Treatment for Acute Childhood Asthma=比較吸入性Budesonide與靜脈注射Betamethasone在治療兒童急性氣喘之療效 |
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作者姓名(中文) | 李明勇; 蔡易晉; 陳俊榮; 楊崑德; 朱德明; 錢新南; 洪志興; | 書刊名 | Journal of Medical Sciences |
卷期 | 24:2 2004.04[民93.04] |
頁次 | 頁85-89 |
分類號 | 418.263 |
關鍵詞 | 吸入性Budesonide; 靜脈注射Betamethasone; 兒童急性氣喘; Asthma; Betamethasone; Budesonide; Exhaled nitric oxide; |
語文 | 英文(English) |
英文摘要 | Background: This study conducted to compare the anti-inflammatory effect of a single does of nebulized budesonide to that of an equal does of intravenous betamethasone in children with acute asthma. Methods: A total of 22 children with asthma, 11 patients in each group were recruited. The children were randomly assigned to: 1) a budesonide (terbutaline and budesonide) group or 2) a betamethasone (terbutaline and betamethasone) group. The pulmonary index score (PIS), peak expiratory flow rate (PEFR), exhaled nitric oxide (eNO) level, and blood pressure of all participants were evaluated before and 1, 3, 6, 7, and 12 hours after treatment. Exhaled nitric oxide (eNO) was used as a marker reflecting airway inflammation. Results: Both nebulized budesonide and intravenous betamethasone effectively decreased eNO 6 and 7 hours, respectively, after treatment. In combination with the nebulized terbutaline for avoiding early hypoxemia and distress, both nebulized and intravenous steroid increased the peak expiratory flow rate (PEFR) and decreased pulmonary index score (PIS) during the whole study period. Conclusions: Results from this study suggest that steroids such as budesonide may provide an equal anti-airway inflammation effect but fewer side effects than the intravenous betamethasone therapy in children with acute asthma. |
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