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頁籤選單縮合
題名 | The Protective Effect of 3-Aminobenzamide on Ischemia-Reperfusion-Induced Liver Injury=3-胺基苯醯胺對缺血再灌流引發肝損傷的保護作用 |
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作者 | 林恆毅; 汪大衛; 蔣桂芳; 陳昭富; | 書刊名 | 輔仁醫學期刊 |
卷期 | 2:2 2004.06[民93.06] |
頁次 | 頁19-26 |
分類號 | 415.53 |
關鍵詞 | 缺血再循環; 肝損傷; 氧游離基; 一氧化氮; 3-胺基苯醯胺; Ischemia-reperfusion; Liver injury; Oxygen radical; Nitric oxide; Aminobenzamide; |
語文 | 英文(English) |
中文摘要 | 背景和目的:缺血的肝組織恢復再灌流後會產生氧化壓力及氮化壓力,因而造成去氧核醣核酸股之斷裂,以致活化了聚核醣二磷酸形成?,造成核內輔?NAD+及三磷酸腺?酸之消失,引起不可逆之細胞毒性。本研究中我們證實聚核醣二磷酸形成?抑制劑3-胺基苯醯胺可減輕缺血/再循環造成之肝損傷。方法:缺血是透過將肝總動脈及門靜脈夾住40分鐘,然後再恢復灌流90分鐘。缺血前及再循環後均抽血以分析血中一氧化氮及甲基胍含量變化而肝損傷指數則以AST和ALT當作指標。結果:此結果證實肝缺血再循環會造成一氧化氮之上升(p<0.01)而表示發炎反應之甲基胍也明顯的增加(p<0.001)。肝功能指數AST及ALT也增加4~5倍(p<0.001)。當給予3-胺基苯醯胺(20mg/kg)後肝損傷明顯地減弱而一氧化氮及甲基胍也一併減少。結論:此研究結果說明3-胺基苯醯胺可透過多種的功能產生抗發炎效果因而減少肝損傷。 |
英文摘要 | Background and Purpose: Reperfusion of an ischemic liver results in the generation of oxidative stress and nitrosative stress, both of which can cause strand breaks in DNA, thus activating nuclear enzyme poly (ADP-ribose) synthase (PARS). This results in rapid depletion of intracellular NAD+ and ATP and eventually induces irreversible cytotoxicity. In this study, we demonstrate that a PARS inhibitor, 3-aminobenzamide, attenuated ischemia/reperfusion (I/R)-induced liver injury. Methods: Ischemia was induced by clamping the common hepatic artery and portal vein of rats for 40 min. Thereafter, flow was restored, and the liver was reperfused for 90 min. Blood samples collected prior to the ischemia and after the reperfusion were analyzed for methyl guanidine (MG), NO, and white blood cells. Blood levels of aspartate transferase (AST) and alanine transferase (ALT), which serve as indices of liver injury, were measured. Results: Results showed that this protocol resulted in elevation of the blood NO level (p<0.01). Inflammation was apparent, as white cells and MG levels were significantly increased (p<0.05 and p<0.001, respectively). AST and ALT were elevated to 4~5-fold of their respective baselines (both p<0.001). After administration of 3-aminobenzamide (20mg/kg), liver injury was significantly attenuated while MG (p<0.001) and NO (p<0.05) releases were reduced. Conclusion: These results indicate that 3-aminobenzamide, presumably by acting through multiple functions, exerts potent anti-inflammatory effects in I/R-induced liver injury. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。