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題 名 | Obsessive-Compulsive Symptoms Associated with Clozapine and Risperidone Treatment: Three Case Reports and Review of the Literature=Clozapine和Risperidone治療期間出現之強迫症狀--三例病歷報告和文獻回顧 |
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作 者 | 柯巧俐; 顏正芳; 陳正宗; 楊尚儒; 鍾偉倫; 楊明仁; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷 期 | 20:6 2004.06[民93.06] |
頁 次 | 頁295-301 |
分類號 | 418.21 |
關鍵詞 | 強迫症狀; 精神分裂症; Obsessive-compulsive symptoms; Clozapine; Risperidone; Schizophrenia; Serotonin-dopamine antagonists; |
語 文 | 英文(English) |
中文摘要 | 從新一代抗精神病藥物 serotonin-dopamine antagonists (SDAs) 被廣泛使用於治療精神分裂症患者以來,治療中出現的強迫症狀已引起臨床治療者的注意。進一步探討強迫症狀生成與使用 SDAs 之間的關聯性,以及它對治療強迫症狀藥物的反應,將有助於增加臨床醫師對此議題的認識,協助受此症狀困擾的患者。我們報告三位精神分裂症患者,他們在接受 clozapine 和 risperidone 治療中出現強迫症狀,在分別接受 fluvoxamine,clomipramine 和 paroxetine 後其強迫症狀嚴重程度逐漸減緩。我們並回顧相關文獻,對於使用 SDAs 所產生的強迫症狀可能的病理學原因做進一步的討論。 |
英文摘要 | Treatment-emergent obsessive-compulsive symptoms (OCSs) have raised concern since the widespread introduction of serotonin-dopamine antagonists (SDAs) for the treatment of schizophrenia. Further investigations of SDA-emergent OCSs and their response to anti-obsessional agents will be beneficial for clinicians in helping patients who suffer from this problem. We present three cases of schizophrenia in which distressing OCSs occurred during clozapine or risperidone treatment. OCSs were assessed consecutively using the Yale-Brown Obsessive-Compulsive Scale. The OCSs of these three patients were responsive to anti-obsessional agents, including fluvoxamine, clomipramine, and paroxetine. We also review the current literature and discuss the possible pathophysiology and psychopathology of SDA-emergent OCSs. |
本系統中英文摘要資訊取自各篇刊載內容。