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頁籤選單縮合
題名 | Significant Prognostic Factors for Vogt-Koyanagi-Harada Disease in the Early Stage=早期原田病之預後指標 |
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作者姓名(中文) | 許淑娟; 郭錫恭; 陳嘉芳; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷期 | 20:3 2004.03[民93.03] |
頁次 | 頁97-105 |
分類號 | 416.746 |
關鍵詞 | 原田病; 預後; 視網膜剝離; Prognosis; Retinal detachment; Vogt-koyanagi-harada disease; |
語文 | 英文(English) |
中文摘要 | 探討原田病急性期之可能預後指標。回顧性研究自1991年至2001間診斷為原田病的病例。排除發病一個月以上才診斷者。病歷摘錄包括年齡、性別、臨床表徵,全身性表徵、復發、治療、合併症及最終視力。漿液性視網膜範圍依離視神經距離分3級(第一級:於視神經周3個視神經盤直徑遠。第二級:比第一級範圍廣,但無下部之網膜剝膜。第三級:下部或全部視網膜剝離者)。共收集31例包括19位男性12位女性。平均年齡38.55±10.63歲。平均追蹤期為33.09個月。有17例有眼外表徵。4例有至少一項合併症,包括7眼白內障,一眼青光眼。49眼(79%)最終視力達6/12以上。統計結果發現年輕者(p=0.023),網膜剝離範圍較少(p=0.006),無色素性變化(p=0.008)或發生合併者(p=0.030)有較佳之視力預後。原田病之視力預後一般不錯,但變數仍多,在急性質,滲液性視網膜剝離的範圍有可能是重要的預後指標。是否可作為治療之指引需待更一進步的研究。 |
英文摘要 | This study identified possible prognostic signs in the acute stage of Vogt-Koyanagi-Harada (VKH) disease in a retrospective chart review of all patients diagnosed with VKH disease between 1991 and 2001. Those who were diagnosed more than 1 month after the onset of ocular symptoms were excluded. Data recorded included age, sex, clinical features, systemic manifestations, recurrence, treatment, complications, and final visual acuity. Exudative retinal detachment was ranked into 3 grades (grade 1:within peripapillary 3 disc diameters and arcade; grade 2:larger than grade 1 but no inferior retinal detachment; grade 3:inferior or total retinal detachment). Of the 31 patients, 19 were males and 12 were females. Mean age at presentation was 38.55±10.63 years. The mean follow-up period was 33.09 months. Extraocular manifestations were present in 17 cases. Four patients had at least one complication, including cataract in seven eyes and glaucoma in one eye. Forty-nine eyes (79%) had a final visual acuity of 6/12 or better. Final visual acuity was significantly better in younger patients (p=0.023) and those who had less extensive retinal detachment (p=0.006), no pigmentary change (p=0.008) and no complications (p=0.030). The visual prognosis of VKH disease is variable, though generally favorable. In the acute stage, the extent of retinal detachment may be an important risk factor for visual outcome. Further study of this factor as an indictor for treatment in necessary. |
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