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題名 | Efficacy of Nocturnal Nasal Positive Pressure Ventilation in Hypercapnic Patients with Severe Obstructive Lung Disease=高二氧化碳分壓之嚴重阻塞型肺疾患者夜間鼻罩正壓通氣治療的成效 |
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作者姓名(中文) | 江玲玲; 劉劍英; 何淑娟; 盛德芳; 余志騰; 林鴻銓; 郭漢彬; | 書刊名 | 長庚醫學 |
卷期 | 27:2 2004.02[民93.02] |
頁次 | 頁98-106 |
分類號 | 415.428 |
關鍵詞 | 高二氧化碳分壓之阻塞型肺疾; 夜間鼻罩正壓通氣; 6分鐘行走測試; 動脈血氣體分析值; Hypercapnic obstructive lung disease; Nocturnal nasal positive pressure ventilation; 6-minute walk test; Arterial blood gas; |
語文 | 英文(English) |
中文摘要 | 背景:本研究是探討高二氧化碳分壓之阻塞型肺疾患者,給了6個月夜間鼻罩正壓通氣治療於動脈血氣體分析值、運動量、呼吸肌功能、及再度住院次數的成效。 方法:這是一個前瞻性與隨機分配之對照研究。27位阻塞型肺疾病患被分至夜間鼻罩正壓氣道通氣治療組(共13人),或控制對照組(共14人)。治療前與6個月的夜間鼻罩正壓通氣治療後測量病患之動脈血壓分析值,運動量,與呼吸肌功能。治療前後6個月期間的住院次數及總住院日亦紀錄之。 結果:夜間鼻罩正壓通氣治療組於6個月治療後,其動脈之二氧化碳分壓,重碳酸離子,及鹼超出量皆下降,且其進步程度與控制組相比有顯著差異。與控制組相比,6分鐘行走距離及每分鐘志願通氣量皆顯著進步,6分鐘行走距離由232.2±79.3米增至333.4±81.3米。夜間鼻罩正壓通氣治療組病患6個月之住院頻率與總住院天數顯著下降。 結論:6個月夜間鼻罩正壓通氣治療能改善高二氧化碳分壓之嚴重阻塞型肺疾患者之動脈血氣體分析值,運動量及呼吸耐力,並且能減低住院次數及總住院天數。 |
英文摘要 | Background: The study objective was to investigate the efficacy of 6 months of nocturnal nasal positive pressure ventilation (NNPPV) on arterial blood gas, exercise capacity, respiratory muscle function, and the frequency of hospital admission in hypercapnic patients with severe obstructive lung diseases. Methods: This was a prospective, randomized, controlled study. Twenty-seven patients with hypercapnic obstructive lung diseases were randomized to either the NNPPV group (N=13) or the control group (N=14). Arterial blood gas, exercise capacity and respiratory muscle function were measured before and after 6 months of NNPPV intervention. The number of hospital admissions and the length of stay during the 6-month period before and after NNPPY intervention were recorded. Results: Subjects in the NNPPV group showed a significant reduction in arterial carbon dioxide partial pressure (PaCO2), bicarbonate (HCO3), and base excess (BE), compared with those before intervention and of the control group, six-minute walk distance (6MWD) also increased significantly from 232.2±79.3 m to 333.4±81.3 m in the NNPPV group after 6 months of intervention. The maximum voluntary ventilation (MVV) also increased significantly after NNPPV intervention. Moreover, the NNPPV group had significantly lower frequency of admission and fewer days of hospital stay during the intervention period compared with those before intervention and of the control group. Conclusion: Six months of NNPPV improved the arterial blood gas, increased exercise capacity and respiratory muscle endurance, and helped to reduce the frequency and the length of hospitalization in hypercapnic patients with severe obstructive lung disease. |
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