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題名 | Effect of Hydroxyapatite Nano-Particle on Properties of Modified Tricalcium Silicate Bone Cements=氫氧基磷灰石奈米顆粒添加對三鈣矽酸鹽骨水泥之影響 |
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作者 | 鍾仁傑; 林昭元; 施並裕; 周鳳英; 金重勳; Chung, Ren-jei; Lin, Chao-yuan; Shih, Ping-yu; Chou, Fong-in; Chin, Tsung-shune; |
期刊 | Journal of Medical and Biological Engineering |
出版日期 | 20031200 |
卷期 | 23:4 2003.12[民92.12] |
頁次 | 頁199-203 |
分類號 | 410.025 |
語文 | eng |
關鍵詞 | 骨水泥; 三鈣矽酸鹽; 自固化; 氧化鋅; 氫氧基磷灰石; 奈米顆粒; Bone-cement; Tricalcium silicate; Self-setting; Zinc oxide; Hydroxyapatite; Nano-particles; |
中文摘要 | 本研究為製備鈣磷系骨水泥材料,三鈣矽酸鹽(C3S, Ca3SiO5)為主要成份,其特點為與水混合後靜置可自行固化。然而由於三鈣矽酸鹽為高溫相,以固態反應法製備時,往往在降溫過程有相分離及不純物的發生。本研究利用添加氧化鋅取代部分氧化鈣,藉以增加三鈣矽酸鹽相的穩定度。由過去的研究中發現添加7.5 mol%的氧化鋅,可最有效降低自由氧化鈣不純相的殘留,然而5 mol%氧化鋅添加的樣品擁有最高的抗壓強度(166 MPa)、較佳的操作性質及較好的流動性。相對來說純C3S固化後之抗壓強度僅在100MPa左右。水泥固化現象約在養護第十天可達到最高抗壓強度。由初步細胞實驗證明,所發展出的水泥材料在成錠後無明顯的細胞毒性。研究中並添加以水熱法製備之氫氧基磷灰石奈米顆粒,以強化最終的水泥產物。結果顯示不同的氫氧基磷灰石添加量將導致不同的硬化時間,7.5 wt%氫氧基磷灰石添加的水泥具有最佳的性質,且可提高含氧化鋅5 mol%水泥的抗壓強度達到175MPa。本研究所發展出的水泥材料無細胞毒性、具有極佳的自固化性及操作性、強度與天然骨骼相近,將來極有潛力應用於骨科及牙科修復。 |
英文摘要 | Solid-state reactions were used to synthesize bone-cements based on zinc modified tricalcium silicate (C3S: Ca3SiO5). C3S is the main self-setting and the fastest hydration constituent in conventional cements. Zinc oxide was added to replace part of CaO in order to stabilize the C3S phase. 5 mole % ZnO addition (Zn-C3S) reveals the best compressive strength that reaches 166 MPa, compared with those without ZnO, 100MPa. In vitro direct-contact-tests using primary cultured osteoblast are persuasive of negligible cytotoxicity. Hydroxyapatite nano-particles prepared through hydrothermal methods were added as strengthener and resulted in the compressive strength increment of the Zn-C3S up to 175 MPa at an HA addition amount 7.5 wt%. The setting mechanism of C3S and Zn-C3S seems to be the same except varied gel properties that extend the fluidity of the slurry. These cements show remarkable self-setting properties and comparable strength with natural bones hence are potential in bony and dental restorations. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。