查詢結果分析
相關文獻
- 利用電腦輔助設計沙弗拉黴素模擬平面化分子之研究
- 以臺灣產茄科中藥調控肝細胞腫瘤中p53及Rb抑癌基因表現與調節修補DNA變異之酵素活性及其在抗腫瘤機轉上的研究
- 6,7-Dimethoxy-1-(2-nitro phenyl)-1,2,3,4- tetra hydroisoquinolines及2,3-dimethoxy-5,6-dihydro indazolo [3,2-a]isoquinoline之合成及結構研究
- Studies on the Synthesis of Isoquinolines as Potential β-Adrenergic Blocking Agents
- Studies on the Synthesis of Isoquinolines as Potential B-Adrenergic Blocking Agent
- Cytotoxic Isoquinoline Alkaloids from Xanthorhiza simplicissima
- Synthesis of Isoquinoline Analogues Modeled after Higenamine
- Inhibitory Effects of Isoquinoline-Type Alkaloids on Leukemic Cell Growth and Macromolecule Biosynthesis
- Screening of Isoquinoline Alkaloids and Their Derivatives for Antibacterial and Antifungal Activities
- 5,6二氫吲唑[3,2α]異喹啉及2,3-二甲氧基-5,6-二氫吲唑[3,2-α]異喹啉之合成及其抗腫瘤活性
頁籤選單縮合
題 名 | 利用電腦輔助設計沙弗拉黴素模擬平面化分子之研究=Study the Plane Saframycin by Computer Simulation |
---|---|
作 者 | 張佑安; 陳冠仲; | 書刊名 | 中州學報 |
卷 期 | 18 2003.12[民92.12] |
頁 次 | 頁241-252 |
分類號 | 418.31 |
關鍵詞 | 沙弗拉黴素; 抗癌機轉; 異喹啉; Saframycin; Antitumor action; Isoquinoline; |
語 文 | 中文(Chinese) |
中文摘要 | 本文是藉由研究沙弗拉徽素(Saframycin)的抗癌機制,利用電腦輔助設計一系列衍生物,以電腦模擬方式來了解這些衍生物是否其有相似的藥性,並於往後計畫中一一由實驗室合成驗證;沙弗拉徽素若以C環為中心,發現此系列天然物具有兩個對稱性的異喹咻雜環架構,且其平面夾角為750;就藥物與DNA的嵌入作用(interchelation)而言,由於立體阻礙因素,非共平面的此架構是相當不利於嵌入作用;且研究沙弗拉徽素的抗癌機轉,了解喹咻環上的取代基和第九碳原子上的支鏈,對細胞毒性的影響很小,若能將此天然物平面化,則將會大大提昇其嵌入效果。 |
英文摘要 | Design and synthesis of the series compounds base the study antitumor action of saframycin, understanding the pharmaceutical property of these compounds by computer simulation. Saframycins are heterocyclic quinone group antitumor antibiotics, which are characterized by their common content of twin heterocyclic quinine moieties; the plane-included angle is 75°. Analyse of drug and DNA intercalation is find that the stereo effect always hammer the effort, investigate adduct of saframycin- DNA detect the longer length of side chain the less intercalation between adduct If we can plane the saframycin compound, we can get the better effect |
本系統中英文摘要資訊取自各篇刊載內容。