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題 名 | Sodium Iodide Symporter (Na狇/I[fed2]Symporter) in Radionuclide Imaging and Radionuclide Therapy=鈉碘共載器於放射核種造影及治療之應用 |
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作 者 | 諶鴻遠; 鄭澄意; 黃文盛; | 書刊名 | 核子醫學雜誌 |
卷 期 | 16:2 2003.06[民92.06] |
頁 次 | 頁85-96 |
分類號 | 414.93 |
關鍵詞 | 鈉碘共載器; 報導基因造影; 基因強化放射核種治療; Sodium iodide symporter; Reporter gene imaging; Genetically enhanced targeted radionuclide therapy; |
語 文 | 英文(English) |
中文摘要 | 鈉碘共載器是一將碘離子藉由細胞鈉離子梯度運轉通過胞膜至細胞內的膜蛋白質,鈉碘共載器之媒介放射碘吸收是臨床用於甲狀腺疾病造影及治療之分子機轉。在鈉碘共載器得以體外複製前,由於核子醫學於甲狀腺及非甲狀腺器官等 影像研究,吾人已明白99mTcO4-亦為鈉碘共載器之另一受質,而且對於鈉碘共載器於身體的組織分佈也略知一二,而今鈉碘共載器的分子特色及其功能表達之節制等研究則更加深我們對其進一步的瞭解。利用加強鈉碘共載器功能表達以促進對甲狀腺癌放射碘治療的策略正在積極進行中,而以鈉碘共載器基因植入非甲狀腺腫瘤並結合放射碘或鈉碘共載器之其他放射性受質治療也已進入動物實驗階段,此外利用鈉碘共載器作為監測轉基因的報導基因造影也是目前部分世界知名實驗室的重點研究之一,由於鈉碘共載器可以用翠光子斷層造影儀配合99mTcO4-為其探針進行影像偵測,兩者在一般核醫部門皆為常規配備毋需昂貴儀器或繁瑣放射製藥之過程,因此極為方便。是故鈉碘共載器是一極具潛力作為放射核種造影及治療之雙重基因。 |
英文摘要 | The Na+/I- symporter (NIS) is the membrane protein mediating iodide translocation across cell membrane into cell using sodium gradient. NIS mediated iodine concentrating activity is the molecular basis for radioiodine imaging and therapy in patients with thyroid disorders. Prior to molecular cloning of NIS, the existence of alternative NIS substrate such as 99mTcO4- and the biodistribution of NIS have been suggested from the practice of nuclear medicine in thyroid and non-thyroid imaging. Now that our understanding of NIS has been expanded through the molecular characterization and regulation of NIS expression. To improve the therapeutic strategy of thyroid cancers by enhancing NIS expression/function has been on trial. Furthermore, a novel therapeutic approach by NIS gene delivery to facilitate radioiodine (or other radioactive NIS substrates) in non- thyroid malignancies has been proposed and studies in animal models. Additionally, the feasibility and useful- ness of NIS gene expression as a reporter to monitor transgene activity is actively investigated in world-class research institutes. As a reporter gene, NIS is more attractive for the readiness of single photon emission tomography and the availability of 99mTcO4- in most nuclear medicine facilities. Thus, NIS has the potential to serve as a dual gene for radionuclide imaging and therapy. |
本系統中英文摘要資訊取自各篇刊載內容。