頁籤選單縮合
題 名 | High Cervical Midline Punctate Myelotomy in the Management of Visceral Pain in the Mouse=高位頸脊髓中軸穿刺治療內臟性腹痛--老鼠模式 |
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作 者 | 張迪生; 林志隆; 劉安祥; 鄭琪云; 吳淑釧; 洪美香; 羅永欽; 郭泰宏; 洪純隆; 黃旭霖; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷 期 | 19:4 2003.04[民92.04] |
頁 次 | 頁159-162 |
分類號 | 415.121 |
關鍵詞 | 脊髓中軸穿刺; 內臟性疼痛; Midline myelotomy; Visceral pain; Writhing test; |
語 文 | 英文(English) |
中文摘要 | 內臟性疼痛之傳導神經路徑,確實位置至今仍不甚明瞭。曾有研究人員嘗試破壞頸脊髓或胸脊髓的中軸以減緩內臟性疼痛。本實驗假設頸脊髓的中軸與傳遞內臟性疼痛的路徑有關。因此,以老鼠為研究對象,破壞其頸脊髓的中軸,再以化學藥物(0.6% acetic acid)打入腹腔,觀察老鼠的疼痛反應。將 36 隻老鼠分為三組:健康對照組、實驗組(第一、二頸脊髓中軸破壞)及實驗對照組(第一、二頸椎椎弓切除,脊髓未破壞)。以 writhing test 計算老鼠的疼痛反應。結果顯示 writhing test 在健康對照組(56.7 10.7)和實驗對照組(50.7 17.4)並無統計學上的意義。然而實驗組(30.0 14.3)與健康對照組或實驗對照組有統計學上的差異(p< 0.001)。因此本實驗證明高位頸脊髓中軸穿刺可以減緩老鼠的腹腔內臟性疼痛。 |
英文摘要 | Increasing evidence implies the existence of a visceral pain pathway in the dorsal column of the spinal cord. Limited midline myelotomy has been used to treat intractable pelvic cancer pain. However, no obvious evidence has been provided that high cervical punctate midline myelotomy (CPMM) relieves visceral pain originating from the abdomen. This study was designed to examine the pain relief effect of CPMM in a mouse model of visceral pain. Thirty-six Institute of Cancer Research (ICR) mice were divided into three groups: Group 1, healthy controls; Group 2, treated with CPMM at C1 and C2; and Group 3, a sham group that underwent laminectomy at C1 and C2 without CPMM. All animals were tested for antinociception in the writhing test 24 hours after surgery. Visceral pain-related behaviors were counted from 5-20 minutes after intraperitoneal injection of 0.6% acetic acid. Writhing test scores were not significantly different between Groups 1 (56.7 ± 10.7) and 3 (50.7 ± 17.4). However, Group 2 (30.0 ± 14.3) showed more than 40% antinociception after treatment, and writhing test scores were significantly different from those of Groups 1 and 3 (p < 0.001). Our results confirm that midline punctate myelotomy can relieve visceral pain and imply that there is a pathway in the posterior funiculus that signals visceral pain. Punctate midline myelotomy at the cervical or high thoracic level may be an alternative strategy in the management of intractable visceral pain due to abdominal or pelvic cancers. |
本系統中英文摘要資訊取自各篇刊載內容。