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題名 | Hormone Replacement Therapy and Menopause: A Review of Randomized, Double-Blind, Placebo-Controlled Trials=賀爾蒙療法隨機雙盲安慰劑控制實驗研究之文獻回顧 |
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作者姓名(中文) | 張玨; 林慧文; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷期 | 19:6 2003.06[民92.06] |
頁次 | 頁257-270 |
分類號 | 418.27 |
關鍵詞 | 荷爾蒙療法; 更年期婦女; 隨機雙盲; 安慰劑; Hormone therapy; Menopausal women; Randomized; Double-blind; Placebo; |
語文 | 英文(English) |
中文摘要 | 荷爾蒙療法常用來治療健康婦女之更年期症狀,及長期使用( 1 年)於預防老年婦女慢性病。本文藉由回顧國際醫學學術資料庫(MEDLINE)關於更年期婦女荷爾蒙使用之利弊,及所發表台灣更年期或荷爾蒙療法之研究,以俾提出台灣未來研究之建議。由於「隨機控制雙盲安慰劑實驗研究」為獲取可靠科學證據的最高標準,本文搜尋 MEDLINE 中自 1966 年 1 月至 2002 年 7 月間有關隨機控制雙盲實驗研究於更年期婦女之荷爾蒙療法,共 23 篇文獻(1年)符合搜尋標準,但並無發現長期追蹤研究於台灣。本搜尋結果顯示,婦女使用各種不同荷爾蒙製劑 1 年以上時,危險性是高於對健康婦女之助益;以及對有心臟疾病、老人失智症、子宮切除、子宮-輸卵管-卵巢切除、或有過中風之婦女並無幫助。如使用相同的 MEDLINE 搜尋於台灣之荷爾蒙療法或更年期有關研究,16 篇文獻符合搜尋標準,但只有一篇為短期荷爾蒙療法研究;而當中並未有任何研究證明長期荷爾蒙療法對於更年期婦女是有益的。 |
英文摘要 | Hormone replacement therapy (HRT) is frequently prescribed to healthy women to ameliorate menopausal symptoms. HRT is used long term (1 year) to prevent chronic disease in older women. The objective of this study was to review the benefits and risks of HRT and studies of menopause or HRT in Taiwan via a MEDLINE search. Recommendations are provided for future HRT research in Taiwan. Randomized, double-blind, placebo-controlled clinical trials are considered the gold standard of scientific evidence. A MEDLINE literature search (January 1966 to July 2002) identified 23 papers on trials (1 year) that met the inclusion criteria. The results showed that various HRT regimens used for more than 1 year caused more harm than good in healthy menopausal women and that there was no benefit for women with coronary artery disease, Alzheimer’s disease, hysterectomy, hysterosalpingo-oophorectomy, and ischemic stroke. None of this research was conducted in Taiwan. A MEDLINE search using the key words “estrogen replacement therapy and menopause in Taiwan†identified 16 studies. There was only one, short-term, HRT trial. No evidence suggested benefits from long-term HRT in menopausal women in Taiwan. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。