頁籤選單縮合
| 題 名 | Metabolic Alkalosis Associated with Malnutrition in Hemodialyzed Patients=血液透析病人代謝性鹼中毒與營養不良有關 |
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| 作 者 | 盧國城; 項正川; 邱建勳; 金惠民; 林石化; | 書刊名 | Journal of Medical Sciences |
| 卷 期 | 23:6 2003.12[民92.12] |
| 頁 次 | 頁323-328 |
| 分類號 | 415.597 |
| 關鍵詞 | 血液透析; 代謝性鹼中毒; 營養; Hemodialysis; Metabolic acidosis; Metabolic alkalosis; Nutrition; |
| 語 文 | 英文(English) |
| 英文摘要 | Background: The association between metabolic alkalosis and nutritional status has not been well-studied in hemodialysis (HD) patients. The aim of this study was to evaluate this association and how correction of alkalosis affects nutrition in HD patients. Methods: Fourteen with HD patients with persistent metabolic alkalosis for at least 3 months were enrolled. A control group consisted of 14 age, sex and BMI matched HD patients without metabolic alkalosis. To correct the metabolic alkalosis, alkalotic HD patients were randomly divided into 2 groups. One (n=7) was treated with altering the dialysate bicarbonate (HCO₃¯) concentration and the other (n=7) with intradialysis amino acid supplementation for 3 months. Nutritional parameters including anthropometry, normalized protein catabolic rate (nPCR), dietary protein intake (DPI), and biochemical markers were evaluated. Results: The mean starting plasma HCO₃¯ concentration (P(subscript HCO3) ) was 28.4±0.5 mmol/L in the alkalotic group. Compared to the non-alkalotic group, alkalotic patients had significantly lower midarm muscle circumference (MAMC), DPI, nPCR as well as serum creatinine BUN, albumin, phosphate, and intact-parathyroid hormone (I-PTH). There were no significant differences in plasma inflammatory markers such as C-reactive protein (CRP) and interleukin 6 (IL-6). Over a period of 3 months, correction of metabolic alkalosis with amino acid supplementation improved nutritional status more than reduction of the dialysate HCO₃¯ concentration. Conclusions: Metabolic alkalosis as a result of low protein intake is associated with malnutrition and correction of the metabolic alkalosis by adjusting dialysate HCO₃¯ concentration does not improve nutritional status in these well-dialyzed HD patients. |
本系統中英文摘要資訊取自各篇刊載內容。