查詢結果分析
相關文獻
- 酒癮患者使用Disulfiram之副作用評估
- 持續性及循環性全靜脈營養方式對大白鼠身體組成及肝臟功能的改變
- 男性的酒癮患者:分類及兩年預後
- 肝切除:術前肝功能評估及術後肝衰竭
- 川崎病之肝功能回顧研究
- 酒癮及其有關問題
- Neurologcial Problems in Chronic Alcoholics
- 最大漸增運動對健康B型肝炎帶原者肝功能的影響
- Pharmacological Functions of Chinese Medicinal Fungus Cordyceps sinensis and Related Species
- Alstrom Syndrome with Hepatic Dysfunction: Report of One Case
頁籤選單縮合
題名 | 酒癮患者使用Disulfiram之副作用評估=Adverse Effects of Disulfiram in the Treatment for Alcoholism |
---|---|
作者 | 黃名琪; 劉士愷; 游正名; 黃智佳; 陳俊興; 黃碧琴; 林式穀; | 書刊名 | 臺灣精神醫學 |
卷期 | 16:3 2002.09[民91.09] |
頁次 | 頁213-221 |
分類號 | 415.8752 |
關鍵詞 | 肝功能; 酒癮; Disulfiram; Liver function; Alcoholism; |
語文 | 中文(Chinese) |
中文摘要 | 目的:本研究旨在暸解以disulfiram協助酒癮病人行戒酒治療時,其肝功能和相關副作用之變化情形。 方法:根據文獻訂定收納個案的標準並簽署同意書,我們追蹤符合DSM-IV酒精依賴診斷的患者,使用disulfiram協助戒酒達三個月以上者,檢測其服用前、服用後三個月及六個月末之肝功能變化,包括SGOT、SGPT、γ-GT,並分析用藥前後之數值差異。同時,對於參與酒癮團體心理治療之患者,以自填問卷方式追蹤並了解其於使用disulfiram後兩週及四週之輕度副作用。 結果:共有203位病患使用disulfiram,其中52位完成三個月及13位完成六個月療程之追蹤。除一位病患因持續飲酒造成三個月末之γ-GT值比原來稍有上昇外,其餘無一造成肝功能數值惡化。三項肝功能平均指數於三個月比原有數值皆呈顯著下降(p<0.01)。在輕度副作用方面,共27位完成問卷,第四週之副作用比率比第二週明顯下降,以嗜睡、易疲倦為主。 結論:本臨床試驗初步顯示,使用disulfiram協助戒酒,在完成三個月及六個月追蹤的有限個案中,未見任何肝臟毒性。而在輕度副作用評估方面,患者報告隨著使用disulfiram的時間增長,其出現比率有下降趨勢。 |
英文摘要 | Objective: The purpose of this study was to examine liver-function test results following disulfiram administered as an adjunct to alcoholism treatment, as well as to evaluate the initial, less-serious adverse effects associated with the use of the drug. Methods: A six-month outpatient program was conducted using alcoholic patients who received 200 mg/day of disulfiram. Patients with initial transaminase levels (both SGOT and SGPT) lower than 100 U/L were allowed to enter the program. Subsequently, these patients underwent follow-up testing to establish both transaminase and γ-GT levels after three and six months on the drug. Patients participating in group psychotherapy were evaluated the less-serious adverse effects using a self-administered questionnaire at the end of the second and fourth weeks. Changes in liver function at baseline and three months were analyzed using the paired t-test after logistic transformation. Results: Fifty-two out of 205 patients using disulfiram completed a three-month follow-up, with 13 completing a six-month follow-up. The average sequential liver-function test results at three months were significantly lower than the respective baselines (p <0.05). All the indexes showed improvement except for one case with elevated γ-GT at six months owing to relapse into alcohol abuse. Analysis of age and gender distribution revealed no difference between patients who completed a three-month follow-up and those who dropped out before that time. The frequency of occurrence for the less-serious adverse effects of disulfiram treatment were decreased from the second to the fourth week for 27 patients, most commonly sleepiness and drowsiness. Conclusion: Disulfiram did not cause abnormal liver-function results in our modest patient sample during the follow-up period. The frequency of the common but less-serious adverse effects reduced with time during the initial four-week period. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。