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題名 | Low-dose Aspirin does not Increase Pregnancy Rates and Uterine Artery Blood Flow Velocity in Male-factor Infertility Patients Undergoing Intracytoplasmic Sperm Injection=服用低劑量阿司匹靈對於因男性不孕症接受單精蟲顯微授精的婦女不會增加其懷孕率及子宮血流 |
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作者 | 林穎慧; 潘咸安; 吳孟興; 張峰銘; | 書刊名 | 臺灣婦產科醫學會會刊雜誌 |
卷期 | 42:3 2003.09[民92.09] |
頁次 | 頁165-169 |
分類號 | 417.125 |
關鍵詞 | 阿司匹靈; 不孕症; 單精蟲顯微授精; 懷孕率; Aspirin; Infertility; Intracytoplasmic sperm injection; Pregnancy rate; |
語文 | 英文(English) |
中文摘要 | 目的:本研究的目的是探討服用低劑量阿司匹靈,對於因男性不孕症接受單精蟲顯微授精的婦女,是否會增加其懷孕率及子宮血流。材料和方法:對象為126名因男性不孕症而接受單精蟲顯微授精的婦女,其中66名從接受gonadotropin注射的第一天開始每天服用80mg 的低劑量阿司匹靈。另外60名婦女則否。結果:兩組病人在刺激排卵的時間長短,血中Estrodiol的濃度(以注射HCG 當天為主),使用gonadotropin的總量,取出的成熟卵數目,植入的胚胎數目皆無明顯差異。臨床懷孕率分別為25 %(有服用低劑量阿司匹靈)及26.5 %(無服用低劑量阿司匹靈)(P> 0.05)。子宮血流則以PI (pulsatility index)及RI(resistant index)做為評估的標準,兩組病人亦無明顯差異。(Pl : 2.3±0.5及RI : 0.8±0.05,有服用阿司匹靈組vs PI: 2.2±0.48及RI : 0.8±0.01,無服用阿司匹靈組)(P> 0.05)。結論:對於因男性不孕症接受單精蟲顯微授精的婦女服用低劑量阿司匹靈不會增加其懷孕率及子宮血流。 |
英文摘要 | Objective: To determine the effects of low-dose aspirin on uterine artery blood flow velocity and pregnancy rate in an unselected group of patients undergoing intracytoplasmic sperm injection (ICSI). Material(s) and Method(s): A total of 126 ICSI procedures were analyzed prospectively. Inclusion criteria allowed only first-trial couples with long-standing infertility caused by a male factor. Besides the exclusion of female factors, the patient population was unselected. The aspirin (+) (n = 66) group received 80 mg aspirin beginning on the first day of the gonadotropin stimulation, and the aspirin (-) (n = 60) group received no treatment. Result(s): Duration of stimulation, serum levels of estradiol on the hCG day; total medication dosage of gonadotropin; numbers of mature oocytes collected; numbers of embryos transferred, were not significantly different. Clinical pregnancy rates were 25.0% versus 26.5% in aspirin treated and untreated groups (P> 0.05). Uterine artery pulsatility index (P1) and resistant index (RI) values on the hCG day were 2.30±0.50 and 0.80±0.05 in aspirin treated group versus 2.20±0.48 and 0.80±0.11 in aspirin untreated group, respectively (P> 0.05). Conclusion(s): Low-dose aspirin (80 mg) appears to have no beneficial effect on uterine blood flow velocity and pregnancy rates in an unselected group of patients undergoing ICSI for male factors infertility. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。