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題 名 | Propofol Inhibits Neuronal Firing Activities in the Caudal Ventrolateral Medulla=Propofol抑制延腦尾腹外側區的神經活性 |
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作 者 | 楊靖宇; 吳文欽; 蔡作雍; 徐至清; 史麗珠; 呂炳榮; 譚培炯; | 書刊名 | 長庚醫學 |
卷 期 | 26:8 2003.08[民92.08] |
頁 次 | 頁570-577 |
分類號 | 418.224 |
關鍵詞 | 延腦尾腹外側區; 細胞外記錄; Propofol; Caudal ventrolateral medulla; Extracellular recording; |
語 文 | 英文(English) |
中文摘要 | 背景:Propofol是一個強效的靜脈注射全身麻醉劑,然而它在中樞神經系統延腦尾腹外側區城(caudal ventrolateral medulla, CVLM)的作用尚未完全清楚,因此我們採用神經細胞外記錄的方法,記錄propofol靜脈注射前及靜脈注射後,延腦尾腹外側區域神經放電活性的變化。 方法:用31隻貓髼為研究的對象,使用-choloralose和urethane腹腔注射全身麻醉,在靜脈注射propofol 2 mg.kg-1及連續追加劑量注射propofol後(1, 1, and 2mg.kg-1),觀察紀錄平均血壓,心跳,及神經放電。一直記錄到神經放電回復到連續注射propofol前的水平。 結果:在連續注射propofol後,(1, 1, and 2 mg.kg-1),神經放電活性呈現劑量依賴忸及可逆性的抑制。對照組的神經放電頻率是17.9±8.6Hz,在第1個劑量注射後,延腦尾腹外側區域的放電頻率減少到15.8±8.5 Hz (p<0.05 vs. the control)。在第2個劑量注射後,放電頻率減少到12.8±8.3Hz(p<0.05 vs. the control)。在第3個劑量注射後,放電頻率更進一步減少到10.0±7.9Hz(p<0.05 vs. the control)。 結論:Propofol劑量依賴性及可逆性的抑制神經放電頻率,是亡在延腦尾腹外側區志主要的藥理作用。 |
英文摘要 | Background: Propofol is a potent intravenous anesthetic. The action of propofol on the medul;lary deparessor area, the caudal ventrolateral medulla (CVLM), has not been well established. We therefore performed extracellular recordings to study the neuronal activity of a the CVLM in cats before and after interavenous propofol administration, to investigate its influence on neuronal firings. Methods: Experiments were performed on 31 cats anaesthetized with a mixture of α-chlorablose and urethane administered intraperitoneally. Mean systemic arterial pressure, heart rate, and the neuronal firing (NF) rate were continuously recorded before and after intravenous injuection of a single does of 2 mg.kg-1propofol or separate supplemental doses of 1, 2, and 4 mg.kg-1 profol unitl those paramenters had retuned firing to the premedication level. Results: propofol dose-dependently and reversibly inhibited the NF rate after the supplemental does of 1, 2, and 4 mg.kg-1 propofol. The control NF rate of 17.9±8.6Hz was depressed to 15.8±8.5Hz after the first dose of propofol (p<0.05 vs. the control), and was further depressed to 12.8±8.3Hz (p<0.05 vs. the control) and 10.0±7.9Hz (p<0.05 vs. the control) after the second and the third doses of propofol, respectively. Conclusion: The dose-dependent inhibition of the spontaneous neuronal firing rate is the main pharamacolgical action of propofol in the caudal ventrolateral medulla of cats. |
本系統中英文摘要資訊取自各篇刊載內容。