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題名 | Prediction of Elevated Cord Blood IgE Levels by Maternal IgE Levels, and the Neonate's Gender and Gestational Age=利用媽媽血中的IgE值與新生兒性別以及懷孕週數可預測臍帶血會有較高的IgE值 |
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作 者 | 劉倢安; 王志祿; 莊好; 歐家佑; 許德耀; 楊崑德; | 書刊名 | 長庚醫學 |
卷期 | 26:8 2003.08[民92.08] |
頁次 | 頁561-569 |
分類號 | 417.596 |
關鍵詞 | 臍帶血; 家族過敏史; 男女性別; 懷孕週數; Cord blood; Immunoglobulin E; Family atopic history; Gender; Gestational age; IgE; |
語文 | 英文(English) |
中文摘要 | 背景:新生兒臍帶血IgE值可用來預測兒童過敬症,我們希望萻由分析父母親的過敏以及懷孕週數、男女性別與出生季節新生兒臍帶血IgE值影響,找出影響臍帶血IgE直的相關因子。 方法:懷孕過程收集父母親過敏史,並於懷孕三期收集父母親的血,臍帶血則是在新生兒出生時收集。血中IgE以及特過敏原IgE的值是利用Phamacia CAP系統來偵測。 結果:總共收集了437個家庭,分析發現男嬰比女嬰有較高的臍帶血IgE值(0.535±0.898 vs. 0.369±0.565 KU/L, p=0.021)以及有較高比例的臍帶血IgE值大於1.01.0 KU/L (14.6% vs. 7.5%, p=0.018)。在初夏以及早冬季節?生的嬰兒有較高的臍帶血IgE值。多變數迴歸分析顯示若媽媽血中有較高的IgE值(OR=6.35; p=0.000)、性別為男嬰(OR=2.31; p=0.021)、以及懷孕週數較大者(OR=1.34; p=0.039)可預測新生兒會有較高的臍帶血IgE值。相反的,父母親的過敏史或者爸爸的血中IgE值則與新生兒臍帶血的IgE 值無相關。 結論:嬰兒的性別、懷孕週數、以及母親血中IgE的值會影響臍帶血IgE值.因此在懷孕期間避免過敏原的接觸以及降低過敏反應對於防止胎兒致敏是很重要的。 |
英文摘要 | Backgorund: Elevation of cord blood immunoglobulin E (IgE) is used to predict childhood atopy. In an effort to catch such problems at an earlier time, we sought to indentify the impact of parental atopy as well as gestational age, the baby’s gender, and the season of delivery on cord blood IgE levels. Methods: The allergic history of parents was collected during pregnancy. Blood samples from parents were collected in the third trimester. Cord blood was collected immediately after birth. Total and specific IgE levels were determined using the Pharmacia CAP system. Results: In total, 437 core family blood samples were collected. Male babies had a significantly higher IgE level (0.535±0.898 vs. 0.369±0.565 KU/L, p=0.021) and a higher frequency of IgE≧1.0 KU/L (14.6% vs. 7.5%, p=0.018) compared to female babies. A cyclic trend in higher cord blood IgE levels was found in babies born in early summer and early winter. Multiple logistic fregression analyses revaled that elevation of cord blood IgE levels could be predicated by higher maternal IgE levels (odds ratio [OR]=6.35; p=0.000), male baby gender (OR=2.31; p=0.021), and increases in gestational age by 1 week (OR=1.34; p=0.039). In contrast, neither the allergic history of parents nor elevation of paternal IgE levels could be correlated with elevated cord blood IgE levels of neonates. Conclusion: The baby’s gender and gestational age, and maternal IgE levels influence cord blood IgE levels. Avoiding allergens and decreasing allergic activities during pregnancy may be the most important means of preventing the fetus from having allergic sensitization. |
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