查詢結果分析
相關文獻
- Heavy Dietary Iron Loading Reduced IRE-Binding Activities of Iron Regulatory Proteins in Rat Liver
- 不同膳食鐵量補充對缺鐵貧血大鼠肝臟鐵調節蛋白活性之影響
- Induction of Hepatic Cytochrome P450 Using Dietary Oxidized Oil in Iron Deficient Rats
- 蛋白質缺乏誘導大鼠肝鐵堆積
- 以放血法減少鐵儲存可改善非酒精性脂肪肝炎且高鐵蛋白血症的患者之胰島素阻抗性:個案對照研究的證據
- 發炎性貧血
- 蘇力菌素對大鼠口服及肺毒性之評估
- Serum Transferrin Receptor Concentration is Not Indicative of Erythropoietic Activity in Chronic Hemodialysis Patients with Poor Response to Recombinant Human Erythropoietin
- 臺灣高鐵融資能解套﹖--挑戰二千八百億
- 農藥免賴得致胚胎畸形及其測試方法之建立
頁籤選單縮合
題 名 | Heavy Dietary Iron Loading Reduced IRE-Binding Activities of Iron Regulatory Proteins in Rat Liver=高鐵餵飼降低大鼠肝臟鐵調節蛋白的IRE結合活性 |
---|---|
作 者 | 何素珍; 蕭寧馨; | 書刊名 | 中華民國營養學會雜誌 |
卷 期 | 28:3 2003.09[民92.09] |
頁 次 | 頁148-157 |
分類號 | 411.38 |
關鍵詞 | 鐵調節蛋白; 高鐵; 鐵蛋白; 大鼠; Iron regulatory proteins; Iron-overloading; Ferritin; Aconitase; Rats; |
語 文 | 英文(English) |
中文摘要 | 鐵調節蛋白(iron regulatory proteins 1 and 2, IRPs)藉由與特定mRNA上的IRE(iron responsive element)結合,影響某些蛋白質的表現,例如:鐵蛋白、運鐵蛋白受體及粒線體aconitase等,進而調節鐵的貯存、獲取及利用,維持細胞鐵的恆定。細胞培養實驗顯示加鐵會使IRP1插入鐵硫聚集轉變為細胞質aconitase,失去與IRE結合的能力,但是不會改變IRP1蛋白質的量。另一方面,鐵會加速IRP2蛋白質的降解作用,進而降低其與IRE結合的量。本實驗的目的乃是探討餵飼高鐵飼料對大鼠肝臟IRPs活性的影響,並觀察鐵蛋白的表現是否受IRPs/IRE系統調控。十二隻離乳SD品系雄鼠,隨機分為二組,分別餵予正常(37mg/kg Fe)及高鐵(2.5% carbonyl iron;25,000 mg/kg Fe)飼料8週,犧牲取樣進行分析。結果發現,高鐵餵飼會使得大鼠肝臟堆積大量的鐵,IRPs的自發性IRE結合活性顯著降低,鐵蛋白表現增加,符合目前已知的調控機制。 |
英文摘要 | Iron regulatory proteins (IRPs)-1 and -2 regulate the synthesis of proteins involved in iron homeostasis through binding to the iron-responsive element (IRE) in the putative mRNA. In cell culture, the iron supplement converts IRPl to the inactive IRE-binding form-cytosolic aconitase, by inserting an iron-sulfur cluster without changing the protein level. In contrast to IRP 1, iron inactivates IRP 2 by promoting its degradation. In addition to examining the effect of a dietary iron overload on the hepatic IRE-binding activities of IRPs in an animal and to determine if the IRPs/IRE system exhibits a regulatory function in relation to the expression of ferritin, rats were fed either a control diet (C, 35 mg/kg Fe) or an iron-overloaded diet (IO, 25, 000 mg/kg Fe) for 8 weeks. In accordance with the current regulatory theory, iron overloading was found to reduce the spontaneous IRE-binding activities of hepatic IRPs. Changes in ferritin content and mitochondrial aconitase activity were consistent with the regulation of their abundance by IRPs. |
本系統中英文摘要資訊取自各篇刊載內容。