頁籤選單縮合
題名 | Both U-74006F and Dexamethasone Inhibit Interleukin-1β Induced Vascular Smooth Muscle Oscillations=二種類固醇試劑(U-74006F及Dexamethasone)都可抑制細胞介質素所引發的血管振盪性收縮反應 |
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作者姓名(中文) | 金忠孝; 陳安; 李偉華; | 書刊名 | Journal of Medical Sciences |
卷期 | 23:2 2003.04[民92.04] |
頁次 | 頁97-104 |
分類號 | 418.22 |
關鍵詞 | 類固醇試劑; 細胞介質素; 血管振盪性收縮反應; Inducible nitric oxide synthase; Oscillation; Tirilazad mesylate (U-74006F); Vascular smooth muscle; |
語文 | 英文(English) |
英文摘要 | Background: Incubation of aortic rings with interleukin-1β(IL-1β) induces spontaneous oscillation during phenyle-phrine-induced contraction. We hypothesized that the steroid compounds, U-74006F and dexamethasone could inhibit the induction of inducible nitric oxide synthase (iNOS) and further inhibit this oscillation. Methods: Rat aortic rings (endothelium removed) were incubated in IL-1β with or without the non-glucocorticoid 21-aminosteriod U-74006F (□M) or the glucocorticoid dexamethasone (□M) for 3,5 or 7 hours. Spontaneous oscillation was induced by contraction with phenylephrine. Results: Oscillation occurred during phenylephrine-induced contraction and L-arginine-induced relaxation (indicator of iNOS activity) in IL-1β incubated vessels. Pretreating the vessels with □-nitro-L-arginine (□M) did not significantly inhibit the phenylephrine-induced oscillation in IL-1β incubated vessels suggesting a non-iNOS mechanism involved in inducing oscillation. The oscillation frequency and magnitude were significantly inhibited by both dexamethasone and U-74006F. Dexamethasone incubation inhibited L-arginine-induced relaxation and augmented phenylephrine-induced contraction when compared to IL-1β incubated vessels which was not observed in U-74006F incubated vessels. Conclusions: U-74006F may have a therapeutic advantage over dexamethasone in that U-74006F could inhibit pathological oscillation activity with minor effects on L-arginine induced relaxation, and contractile responses to phenylephrine. |
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