頁籤選單縮合
題名 | Baclofen-induced Reversible Akinetic Mutism=Baclofen引起之可逆性運動不能靜默症 |
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作者 | 陳軾正; 許燿東; 彭家勛; | 書刊名 | Acta Neurologica Taiwanica |
卷期 | 12:2 2003.06[民92.06] |
頁次 | 頁89-92 |
分類號 | 418.24 |
關鍵詞 | 可逆性運動不能靜默症; Akinetic mutism; Baclofen; Chronic renal insufficiency; Periodic triphasic waves; |
語文 | 英文(English) |
英文摘要 | A 73-year-old woman who had type 2 diabetes with chronic renal insufficiency developed akinetic mutism after baclofen use for chronic lumbago. Her mental state recovered dramatically in two days after discontinuing baclofen. The electroencephalography (EEG) showed a background of diffuse slow waves with periodic triphasic waves. The brain magnetic-resonance imaging showed brain atrophy without features of acute strokes. Current diagnosis of baclofen-induced akinetic mutism is based on clinical history and the findings of EEG. The underlying pathophysiology is not yet clear, which may be caused by selective binding of the γ-aminobutyric acid-B receptors with interruption of thalamocortical limbic pathways in the frontal lobes. This report indicates that akinetic mutism might be induced by baclofen use in patients with severely impaired renal function. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。