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題 名 | Effects of Xuefu Zhuyu Tang and Mitomycin C on Liver Tumors in Mice=血府逐瘀湯與絲裂黴素對鼷鼠肝腫瘤的效應研究 |
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作 者 | 游智勝; 黃蕙棻; 郝道猛; | 書刊名 | 長庚醫學 |
卷 期 | 26:6 2003.06[民92.06] |
頁 次 | 頁417-424 |
分類號 | 414.52 |
關鍵詞 | 血府逐瘀湯; 絲裂黴素; 實驗性肝腫瘤; Xuefu zhuyu tang; Mitomycin C; Experimental liver tumor; |
語 文 | 英文(English) |
中文摘要 | 背景:中醫認為腫瘤的成是由於”氣滯血瘀”,氣血瘀以致有毒的物質滯留體內,血府逐瘀湯是”理氣活血”的代表方劑,而絲裂黴素為一廣泛使用的抗腫瘤藥物。本研究即是觀察以上二者對鼷鼠肝腫瘤的治療效應。 方法:以肉瘤180細胞接種在鼷鼠肝臟後,隨機分為四組,包括腫瘤對照組、血府逐瘀湯組、絲裂黴素組,以及血府逐瘀湯與絲裂黴素的合併組。我們觀察了鼷鼠肝腫瘤在治療後60天內的存活率,平均存活時間與延長壽命程度,並且把腫瘤取下後檢測其細胞存活率與生物合成速率。 結果:血府逐瘀湯組、絲裂黴素組與合併組相較於對照組分別增加鼷鼠存活時間為12.5,14.1,與17.2日。這三組治療對肝腫瘤細胞具有毒殺作用,對生物合成速率有制作用。其中合併組的療效最佳。 結論:本研究結果顯示,血府逐瘀湯合併絲裂黴素的治療模式,可提供肝腫瘤治療的參考,其機制有待進一步的探討。 |
英文摘要 | Background: Carcinogenesis, in traditional Chinese medicine, is defined as resulting from the accumulation of stagnant and toxic substances within the human body. Xuefu zhuyu tang (XZT) represents a group of herbs for ‘destagnation’; and mitomycin C (MMC) is currently and widely used for cancer theraphy. We investigated the combined effects of XZT and MMC on mice bearing liver tumors. Methods: Mice bearing experimental liver tumors were divided into 4 groups, including tumor control, XZT-, MMC-, and combined-treatment groups. Several span, and mean survival time within 60 days after treatment. Survival rates and biosynthesis activities of tumor and liver cells were also evaluated. Results: Oral administration of XZT, an intraperitoneal injection of MMC, and a combination of the two increased the mean survival time of tumor-bearing mice by 12.5, 14.1, and 17.2 days, respectively. These 3 treaments were cytotoxic to sarcoma-180-induced liver tumor cells. The synthesis rates of deoxyribonucleic acid (DNA), ribonucleic acid (RNA), and protein by tumor cells were all measurably inhibited by the combined treatment. Conclusion: XZT combined with MMC may be an effective modality in cancer therapy. The detailed mechanisms of these combinations in human liver neoplasms use to be further studied. |
本系統中英文摘要資訊取自各篇刊載內容。