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相關文獻
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頁籤選單縮合
題名 | Topical Cyclosporine Therapy for Keratoconjunctivitis Sicca in Sjogrens' Syndrome=局部環孢靈素對眼部乾燥症的治療 |
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作者姓名(中文) | 樊文雄; 洪豪良; 廖旭彬; 賴寧生; | 書刊名 | 慈濟醫學 |
卷期 | 15:2 2003.04[民92.04] |
頁次 | 頁85-89 |
分類號 | 416.753 |
關鍵詞 | 環孢靈素; 眼部乾燥症; 淚液分泌; Cyclosporine; Keratoconjunctivitis sicca; Tear secretion; |
語文 | 英文(English) |
中文摘要 | 目的:本研究旨在探討局部點用環孢靈素治療眼部乾燥症的效用與安全性。病人與方法:共收集50位病患分為實驗組及對照組,實驗組用0.1%環孢靈素加油性介質,對照組則只用油性介質,兩組眼藥每天使用兩次,期間為三個月。本研究以症狀嚴重度、基礎淚液分泌及眼裂間活體染色做為評估標準。結果:在臨床症狀方面兩組皆有改善,但不具統計學上明顯的差異。基礎淚液分泌在第三個月及眼裂間活體染色在第一個月及第三個月,兩組皆具有統計上明顯的差異。結論:本研究結果顯示,局部環孢靈素可以控制眼部乾燥症的發炎反應及恢復基礎淚液的分泌。 |
英文摘要 | Objective: This study aimed to investigate the therapeutic effect and safety of topical Cyclosporine 0.1% in Keratoconjunctivitis sicca associated with Sjögrens' syndrome. Patients and Methods: Fifty patients with Sjögrens' syndrome associated Keratoconjunctivitis sicca were divided into two groups. Topical Cyclosporine (CsA) or vehicle control was applied twice a day for 3 months. The severity of symptoms, interpalpable Rose Bengal staining scores and Schirmer values were used as outcome evaluations. Results: Subjective symptoms improved in both groups at all intervals; however they did not show any statistical significant difference. The CsA group had a statistically significant improvement in Schirmer value in month 3, and staining scores in month 1and 3 compared with the control group. Conclusion: Topical Cyclosporine treatment may provide control of ocular surface inflammation and reproduction of baseline tear secretion. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。