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題 名 | Immunohistochemical Study on the Expression of p-53 Protein in Gastric Cancer=胃癌p-53蛋白表現的免疫組織化學研究 |
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作 者 | 孫家棟; 李威傑; 洪瑞隆; 陳炯年; 游憲章; 李伯皇; 張金堅; 陳楷模; | 書刊名 | 中華民國外科醫學會雜誌 |
卷 期 | 29:1 民85.01-02 |
頁 次 | 頁5-11 |
分類號 | 416.243 |
關鍵詞 | 胃癌; p-53蛋白; 免疫組織化學; Gastric cancer; p53 protein; Immunohistochemistry; |
語 文 | 英文(English) |
中文摘要 | 本研究是以免疫組織化學法研究I49例原發胃癌的p53腫瘤抑制基因蛋白表現。其中27例(18.1)的腫瘤具有可代表基因突變的陽性染色。p53蛋白表現與包括年齡、性別、腫瘤部位、肉眼型態、腫瘤大小、組織型態、侵犯深度、淋巴結轉移、遠處轉移、期別等各種臨床病理因素無關。但是在I例轉移的淋巴結申,有5例具有p53蛋白表現陽性染色,其中包括2例原發腫瘤為陰性染色的病例。這顯示p53蛋白表現與胃癌的轉移可能有關。p53蛋白表現陽性病人的存活率較陰性表現的病人為差(P=0.078)。但是在分層分析中,p53蛋白表現陽性僅與廣泛型胃癌預後不良有關而與腸型胃癌無關。這些發現顯示,在胃癌病例中,p53變異的存在與胃癌的轉移可能有關,但是p53蛋白的存在與否僅與廣泛型胃癌預後不良有關。 |
英文摘要 | Overexpression of the tumor suppressor p53 was investigated by immunohistochemistry in 149 primary gastric cancer cases. Positive staining,regarded as an indication of gene mutations, was evident in 27 (18.1) ofthe tumors. No correlation was observed between expression of p53 andvarious clinicopathological factors, including age, sex, tumor site, grosstype, tumor size, histologic type, depth of invasion, node metastases, distant metastases and TNM stage. However, 5 of the cancer cells in the 10metastatic lymph nodes stained positively for p53 even in primary tumornegative patients, implying that gastric cancer with a mutant p53 has highmetastatic potential and metastases to lymph nodes probably occur. Survival analysis revealed that for patients with p53-expressing tumors, theprediction was worse than those with non-p53 expressing tumors (p=0.078).Further analysis revealed a significant survival difference for diffuse typegastric cancer but not for the intestinal type. These findings indicate that,in the case of human gastric cancer, overexpression of p53 is associatedwith the metastatic potential of gastric cancer and the presence or absenceof p53 may serve as a prognostic indicator in patients of diffuse type gastriccancer. |
本系統中英文摘要資訊取自各篇刊載內容。