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題 名 | Biological Evaluation of an Antibiotic DC-81-Indole Conjugate Agent in Human Melanoma Cell Lines=抗生素DC-81和Indole Moiety結合成的混成試劑對黑色素腫瘤細胞活性之研究 |
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作 者 | 胡婉萍; 余幸司; 陳彥吉; 王志鉦; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷 期 | 19:1 2003.01[民92.01] |
頁 次 | 頁6-12 |
分類號 | 418.31 |
關鍵詞 | 比咯苯偶氮駢; 黑色素腫瘤; XTT測試; Pyrrolo[2,1-c][1,4]benzodiazepines; PBDs; DC-81; Indole carboxylate moiety; Melanoma; XTT assay; |
語 文 | 英文(English) |
中文摘要 | 由於比咯苯偶氮駢(PBDs)具有辨識 DNA 鹼基對序列,可與特定 DNA 序列形成共價結合,因此 PBDs 對核酸的合成,是一種有效的抑制劑。DC-81 是 PBDs 的一族,由鏈黴菌所分離出來的抗癌抗生素。我們已設計合成出以 DC-81(1)為主體和 indole carboxylate(IC)2 結合成的混成試劑 3,此設計是考慮混成試劑 3 可增加 DNA 序列選擇性。本論文就混成試劑 3 對黑色素腫瘤細胞的活性作一研究,經由細胞毒殺試劑 XTT 測試,結果發現混成試劑 3 對黑色素腫瘤細胞具有較強的細胞毒性。 |
英文摘要 | Pyrrolo[2, 1-c][1, 4]benzodiazepines (PBDs) are potent inhibitors of nucleic acid synthesis because of their ability to recognize and bind to specific sequences of DNA and form a labile covalent adduct. DC-81, an antitumor antibiotic produced by Streptomyces species, is a PBD. We combined DC-81 and an indole carboxylate moiety to synthesize a hybrid designed to have much higher sequence selectivity in DNA interactivity. In this paper, the cytotoxic potency of the hybrid in human melanoma cell lines was studied. XTT assay demonstrated that the DC-81- indole conjugate possessed cytotoxicity against human melanoma cell lines. |
本系統中英文摘要資訊取自各篇刊載內容。