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題名 | Biologic Effects of Calcipotriol and Cyclosporine on Psoriatic Skin: A Comparison Study=使用Calcipotriol和Cyclosporine治療乾癬病灶之生物效應:比較研究 |
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作者姓名(中文) | 藍政哲; 吳姿滿; 楊森安; 余幸司; 陳柏宏; 陳國熏; | 書刊名 | 中華皮膚科醫學雜誌 |
卷期 | 21:1 2003.03[民92.03] |
頁次 | 頁16-24 |
分類號 | 415.731 |
關鍵詞 | 乾癬; Calcipotriol; Cyclosporine; Psoriasis; Ki67; |
語文 | 英文(English) |
中文摘要 | 即使乾癬目前已被廣為了解,但其致病原因仍未完全明朗。至今有相當多的治療方式被應用,calcipotriol和cyclosporine即為其中之一。雖然兩者作用機轉不同,但皆可用來治療乾癬。本研究比較乾癬病灶經calciportiol和cyclosporine治療後的表皮厚度,發炎,增生及分化指標(neutrophil elastase, ki67Ag, involucrin)。結果顯示唯有ki67的表現在兩者間有顯著的不同。 |
英文摘要 | Though the understanding of psoriasis has undergone a great improvement, the exact pathogenesis of this disease remains unclear. Numerous modalities have been used for treatment of psoriasis. Calcipotriol and cyclosporine are among the armamentaria. Though acting through different mechanisms, both agents can be used to treat psoriatic lesions. This study compared epidermal thickness andmolecular markers of inflammation, proliferation, and differentiation, i.e. neutrophil elastase, ki67 antigen (Ag), involucrin, between psoriatic lesions before and after treating by either calcipotriol orcyclosporine. The results demonstrated that only ki67 expresion was significantly different among thetwo groups. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。