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題名 | 延胡索成份四氫巴馬汀對癲癇之影響=Effects of d1-Tetrahydropalmatine on Experimental Epilepsy |
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作者 | 林茂村; |
期刊 | 中醫藥年報 |
出版日期 | 19970500 |
卷期 | 15:2 1997.05[民86.05] |
頁次 | 頁316-333 |
分類號 | 414.5 |
語文 | chi |
關鍵詞 | 四氫巴馬汀; 癲癇; 妥巴胺; 杏仁核; 動脈壓; Tetrahydroxy palmatine; Epilepsy; Dopamine; Amygdala; Arterial pressure; |
中文摘要 | 本研究旨在於探討四氫巴馬汀 (THP) 對於實驗性癩癇之影響。癩癇發作之誘發採 用皮下注射 picrotoxin 與杏仁核內電刺激等兩種模式。我們利用自行研發的紅外光矩陣式 與超音波式行為量測系統來分析大白鼠癩癇發作時的量化程度。實驗結果顯示,不論是化學 性或電氣性誘發癩癇發作時,大鼠之 tremor,myoclonia,turning 與 locomotion 均有顯 著增加, 其動作增加之幅度均與癩癇發作之程度,兩者具有相關性。 同時,我們發現給予 THP 確實可以抑低化學性或或電氣性引致的癩癇發作。 大鼠的動作增加現象也可被 THP 之 服用所抑低。在全身麻醉下給予 picrotoxin 除了可誘發大鼠的癩癇發作 (例如肌體抽搐不 斷 ) , 同時提昇動脈壓以及杏仁核記錄到的妥巴氨釋放。 THP 服用後大大地抑制 picrotoxin 所引致的杏仁核妥巴氨釋放,動脈壓昇高與肌體抽搐。 由本實驗結果推論,延 胡索成份四氫巴馬汀可經由抑制鼠腦杏仁核妥巴氨釋放而達其抑制癩癇發作之作用。由此可 見 THP 可能具有抗癩癇作用。 |
英文摘要 | The purpose of the present study was to assess the possible therapeutic effects of d1-tetrahydropalmatine (THP) on experimental epilepsy. Experimental epilepsy was induced by subcutaneous injection of picrotoxin or direct electrical stimulation of the amygdala of the rat brain. The behavioral responses displayed by the animals to picrotoxin injection or intra-amygdala stimulation were measured by an ultrasonic motion- sensing system designed by ourselves. It was found that the experimental epilepsy or the behavioral responses to chemical or physical stimulation was significantly suppressed by premedication with THP administration. In addition, the pressor responses occurred during the experimental epilepsy were also attenuated by premedication with THP. Furthermore, the increased release of dopamine in the amygdala during experimental epilepsy was suppressed by THP treatment. The data indicate that THP may act through inhibition of amygdala dopamine release to protect the animal from epileptic attack. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。