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題名 | 甲醇中毒的加護治療=Intensive Management for Methanol Intoxication |
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作者姓名(中文) | 洪東榮; | 書刊名 | 中華民國重症醫學雜誌 |
卷期 | 5:1 2003.01[民92.01] |
頁次 | 頁30-38 |
分類號 | 418.82 |
關鍵詞 | 甲醇; 甲酸; 酒精去氫酶; Methanol; Formic acid; Alcohol dehydrogenase; |
語文 | 中文(Chinese) |
中文摘要 | 在臺灣,甲醇中毒並不常見,只有零星個案發生,個案常由於誤喝含甲醇的工業酒精、酒精膏或含甲醇溶劑的農藥。由於米酒價格的飛漲,讓假酒重新活躍在市場上,甲醇是假酒中的一種,因此有甲醇中毒的流行。甲醇中毒最主要來自其代謝物甲酸,其典型的中毒特徵包括明顯的酸中毒、視神經發炎和中毒症狀的延遲出現。實驗室上,病人表現明顯酸中毒合併高陰離子差及滲透壓差時必須將甲醇中毒列入鑑別診斷。積極性的治療以矯正酸中毒,給于葉酸以催化甲酸轉變成二氧化碳和水,以酒精去氫酶抑制劑來抑制甲醇的代謝及適時的血液透析治療是甲醇中毒治療和避免併發症的不二法門。 |
英文摘要 | Methanol intoxication was not so common before. Sporadic cases of methanol intoxication occurred while mis-swallowed of suicide with industrial solvent and alcohol fuel. Due to the cost appreciation of rice wine, an outbreak of epidemic methanol intoxication occurred in the late of 2002. the metabolite, formic acid is the toxic principle of methanol poisoning. The typical presentations of methanol intoxication are severe metabolic acidosis, optic nerve damage and the delayed occurrence of toxidromes. In laboratory examination, methanol intoxication must be considered in cases of high anion gap metabolic acidosis with high osmolal gap. Intensive treatment with acidosis correction, folic acid to catalyze formic acid, alcohol dehydrogenase inhibitors to block toxic metabolities and adequate hemodialysis are the fundamental principles in treatment of methanol intoxication. |
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