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題名 | Preliminary Normal Reference Values of Nuchal Translucency Thickness in Taiwanese Fetuses at 11-14 Weeks of Gestation=臺灣胎兒在懷孕11-14週之頸部透明帶厚度之初步正常參考值 |
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作者姓名(中文) | 徐振傑; 謝景璋; 江其鑫; 羅良明; 謝燦堂; | 書刊名 | 長庚醫學 |
卷期 | 26:1 2003.01[民92.01] |
頁次 | 頁12-19 |
分類號 | 417.14 |
關鍵詞 | 頸部透明帶; 頭臀徑; 中位值倍數值; 唐氏症篩檢; Nuchal translucency; Crown-rump length; CRL; Multiple of median; MoM; Down's syndrome screening; |
語文 | 英文(English) |
中文摘要 | 背景:探討臺灣正常胎兒在懷孕11至14週之頸部透明帶厚度的正常參考值。 方法:從1998年到2001年,前瞻性研究在懷孕11至14週使用超音波測量724名正常胎兒的頸部透明帶厚度。使用回歸分析頸部透明帶厚度和每5mm間距頭臀徑的相關性。頸部透明帶厚度依相對的頭臀徑迴歸後的標準中位值再換算成中位值倍數值(MoM)。母視年齡和頸部透明帶厚度合併計算三染色體21的評估危險機率。 結果:懷孕初期之頸部透明帶厚度會隨著頸透明帶厚度會隨著頭臀徑和懷孕週數的增加而增加,懷孕11-14週的頸部透明帶厚度平均值(中位值)是1.56(1.50)毫米。頸部透明帶厚度中位值倍數值的對數值呈正常常態分布,其平均值是-0.0062,而標準誤差是0.1146。本研究族群裡的頸部透明帶厚度大於等於2.5mm和大於等於3mm的比例,則分別是1.7%(12/724)和0.7%(5/724)。使用母親年齡和頸部透明帶厚度合併計算三染色體21的評估包危險機率超過1:300的有18名(2.5%)。 結論:由於頸部透明帶的每週中位值不同的和人種差異,如要發展懷孕初期頸部透明帶厚度篩檢,應先建立頸部透明帶厚度之正常參考值,將其轉換成中位值倍數以用於計算三染色體21的評估危險機率。 |
英文摘要 | Background: To investigate normal reference values of nuchal translucency (NT) thickness in normal Taiwanese fetuses between 11 and 14 weeks of gestation. Methods: A prospective study of ultrasound measurements of fetal NT and crownrump length (CRL) at 11-14 weeks of gestation was conducted in 724 consecutive Taiwanese fetuses between 1998 and 2001. The relationship between NT and 5-mm intervals of the CRL of the fetus was analyzed. NT thickness was conerted into multiple of median (MoM) values for the proper CRL. The estimated risk of trisomy 21 was calculated in combination with maternal age and NT MoM. Results: NT thickness increased with increasing CRL and gestational week in the first trimester. The mean (median) of NT thickness at 11-14 weeks was 1.56 (1.50)mm. Values of NT MoM showed a normal Gaussioan distribution with a mean of -0.0062 and standard deviation of 0.1146. The overall frequency of NT thickness of >2.5mm and >3.0mm was 1.7% (12/724) and 0.7% (5/724), respectively. There were 18 (2.5%) of 724 normal fetuses with the eseimated risk of trisomy 21, based on maternal age and NT thickness higher than 1:300. Conclusions: Because of weekly variations and racial differences in NT measurements, normal reference values should be established to convert NT thickness into MoM values for calculating the estimated risk of trisomy 21 in first –trimester NT screening. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。