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題名 | The Effects of Low-Level Laser Irradiation on Experimental Fracture Healing=低能量雷射理療對實驗性骨折癒合的探討 |
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作者姓名(中文) | 錢佑; 翁仁政; 過傳良; | 書刊名 | 中華民國口腔雷射醫學雜誌 |
卷期 | 1:1 2002.07[民91.07] |
頁次 | 頁8-14 |
分類號 | 416.36 |
關鍵詞 | 低能量雷射治療; 骨折; 氦氖雷射; 半導體雷射; LLLT; Bone fracture He Ne laser; HYP; Diode laser; |
語文 | 英文(English) |
中文摘要 | 本實驗之目的在探討低能量雷射理療其雷射波長和照射劑量對治療結果之影響孰重。實驗設計使用一臺功率30毫瓦之氦氖雷射及一臺功率200毫瓦之二極體雷射來照射實驗性骨折之大白鼠。總計75隻大白鼠,自其後腿腓體和脛骨之中央部位作人工骨折處理後,隨機分組成控制組和實驗組。雷射照射分別為每天4.5和9.0焦耳/平方公分,大白鼠於實驗起始日起,隔日測量體重後每組犧牲壹隻作組織切片,以檢查其骨骼中Hydroxyproline(HYP)之含量,結果顯示當大白鼠作骨折手術後體重有顯著減輕,但是雷射照射組之體重增加速度較未照射雷射控制組有顯著增加(P <0.05)而HYP之在骨骼中之含量隨照射之累積時間而增加,尤其在實驗組D,其照射劑量每次為9.0焦耳/平方公分,對骨癒合之促進有明顯加強。 成功的低能量雷射理療之重要因素包括照射劑量,能量密度和使用之雷射種類(波長),我們嘗試找出研究各種因素之理想值組合。希望利用此初步之結果,能進一步研究找出對不同組織照射不同波長光其吸收利用之最適當能量密度關聯,以了解低能量雷射治療之機轉及利用。 |
英文摘要 | The purpose of this study was to clarify whether low-level laser therapy (LLLT) is wavelength or dose-dependent. A 30 mW power output He-Ne laser (632.8nm), and a 100 mW diode laser at 808 nm were used for this study on experimental fracture healing in rats. Seventy-five rats were given fractures in the middle of the left tibia and fibula. They were randomly divided into experimental and control groups and irradiated using energy fluences between 4.5 and 9.0 J/cm2. The animals were sacrificed at 4, 8 and 12 days after receiving the fractures. The changes in body weight and hydroxyproline (HYP) content were observed. The results demonstrated that the body weight of the groups that received fractures decreased significantly, especially the control group. Groups irradiated with lasers increased body weight more rapidly than the control group (p<0.01). The HYP content in the fractured bones increased in a time-dependent manner in the laser irradiated groups. The most effective healing acceleration occurred in-group D, which received the highest energy density (9.0 J/cm2) with an 808-diode laser. Group D healed more rapidly and thoroughly than the other groups. The main factors in successful low-level laser therapy (LLLT) include the dosage, laser energy density and laser type optimization. We attempted to create a practical protocol for the use of LLLT in clinical therapy. Further investigations to determine the maximal light absorption by different tissues and the role of wavelength in LLLT are necessary. |
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