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題名 | 對臺灣精醫15卷4期[揚延光等著]“精神分裂症之生理病理學”的評語=Comments on “Pathophysiology of Schizophrenia”, Taiwanese J Psychiatry Vol.15 no.4 |
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作者 | 陳金柱; | 書刊名 | 臺灣精神醫學 |
卷期 | 16:3 民91.09 |
頁次 | 頁249-251 |
分類號 | 415.983 |
關鍵詞 | 精神分裂症; 生理病理學; 性荷爾蒙; |
語文 | 中文(Chinese) |
英文摘要 | Gonadol hormones are distributed in the extrahypothalamic system known as the mesolimbic system.Luteinizing hormone secreted after puberty increases up to 100 times in females and only 30 times in males. The onset of schizophrenia in females is later after puberty than in males, and this timing is correlated with the increased secretion of gonadol hormones.The neuroprotective effect of estrogen in the brain may favor the later onset of schizophrenia in females. Clozapine, the first atypical antipsychotic drug, has greater affinity for the D3 dopamine receptor in the mesolimbic system, while classic antipsychotic drugs have more affinity for the D2 dopamine receptor in the nigrostriatal system, and thus induce more motor side effects. |
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