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題 名 | Gold(III)-Induced Oxidation of Amino Acids and Malonic Acid--Reaction Pathways Studied by NMR Spectroscopy with Isotope Labelling |
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作 者 | Zou,Juan; Parkinson,John A.; Sadler,Peter J.; | 書刊名 | Journal of the Chinese Chemical Society |
卷 期 | 49:4 2002.08[民91.08] |
頁 次 | 頁499-504 |
分類號 | 345.2 |
關鍵詞 | Gold(III) complex; Amino acid; Malonic acid; NMR spectroscopy; Isotope labelling; |
語 文 | 英文(English) |
英文摘要 | Reactions of Au(III) with biomolecules are of interest in relation to understanding the mechanism of action of therapeutic gold compounds. NMR investigations of □C and □N isotopically-labelled glycine and alanine show that Au(III) induces deamination and subsequent decarboxylation of both amino acids with the same mechanism. For comparison, reactions of Au(III) with sarcosine and the dicarboxylic acid malonic acid were also investigated. The major intermediates and products have been identified. ave been identified. |
本系統中英文摘要資訊取自各篇刊載內容。